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Guidelinesforthe diagnosis andtreatment oftinea corporis andtinea crurisin China The Working Group on Guidelinesforthe Diagnosis and Treatment of Tinea corporis and Tinea Crurisin China Chinese Journal of Mycology    2023, 18 (3): 193-197.   Abstract （273）      PDF （740KB）（470）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2022, 17 (3): 177-182.   Abstract （178）      PDF （1558KB）（356）       Knowledge map    Save Reference | Related Articles | Metrics

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Study on the synergistic antifungal activity of glyceryl monostearate and caspofungin in vitro QIU Lijuan, CHAO Wen, SHI Anzhe, YAN Lan, LYU Quanzhen, JIANG Yuanying Chinese Journal of Mycology    2021, 16 (3): 145-149,165.   Abstract （349）      PDF （2161KB）（335）       Knowledge map    Save Objective In order to improve the antifungal effect of caspofungin, we screened the synergistic effects of many compounds with caspofungin in vitro. Methods The minimum inhibitory concentration (MIC) and synergistic index (FICI) of glyceryl monostearate (GMS), caspofungin (CAS) and fluconazole (FCZ) against Candida were measured by a microdilution method. In addition, the minimum concentration of glyceryl monostearate and caspofungin used alone or in combination to inhibit the hyphae formation of Candida albicans was investigated in the RPMI 1640 and Spider medium. Results The combination of glyceryl monostearate and caspofungin showed synergistic antifungal effect on pathogenic Candida, and the synergistic index was less than 0.5. When combined with glyceryl monostearate, the concentration of caspofungin inhibiting the formation of hyphae decreased significantly. Conclusion Glyceryl monostearate could enhance the antifungal effect of caspofungin in vitro. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2022, 17 (2): 89-93.   Abstract （102）      PDF （1299KB）（222）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (3): 265-269.   Abstract （67）      PDF （884KB）（222）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2022, 17 (4): 319-323.   Abstract （50）      PDF （847KB）（200）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2022, 17 (4): 349-352.   Abstract （46）      PDF （814KB）（189）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (1): 58-64.   Abstract （85）      PDF （1484KB）（183）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2021, 16 (3): 202-206.   Abstract （197）      PDF （740KB）（182）       Knowledge map    Save Reference | Related Articles | Metrics

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Distribution and epidemic trend of Candida isolates from patients with oral candidiasis SONG Yang, HE Jing, HE Chun Chinese Journal of Mycology    2021, 16 (3): 166-169,181.   Abstract （447）      PDF （769KB）（172）       Knowledge map    Save Objective To analyze the distribution and epidemic trend of Candida isolates from oral candidiasis patients in our hospital in recent five years retrospectively. Methods A total of 27,162 saliva culture samples collected from the Mucosal Department of Peking University Hospital of Stomatology between 2015 and 2019 were retrospectively analyzed. All the results were entered into the Excel form and analyzed in groups according to different species distribution, funged quantities, sexes and ages. Results Among all the Candida strains isolated from oral candidiasis patients from 2015 to 2019, Candida albicans accounted for the highest proportion, while the positive proportion of Candida tropicalis and other Candida increased year by year. In the samples infected by C. albicans, C. tropical and C. glabrata, the number of colonies was mainly ≥200 CFU/mL. However, the number of colonies in samples infected with C. kruseii and other Candida species is mainly ≤30 CFU/mL or ≥200 CFU/mL. In all study populations, the positive rate of infection in female patients was significantly higher than that in male patients (P<0.05), and the positive rate of oral infection generally increased with age and increased significantly after the 41~50 age group. Conclusion Although Candida albicans was still the main pathogen of oral Candida infection, the positive rate of Candida tropicalis and other Candida had been increasing year by year in recent years. The analysis of the distribution and epidemic trend of oral candidiasis might be useful for clinical medication strategy. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2021, 16 (3): 196-201.   Abstract （200）      PDF （808KB）（166）       Knowledge map    Save Reference | Related Articles | Metrics

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Meta-analysis of trimethoprim-sulfamethoxazole combined with caspofungin in the treatment of Pneumocystis jirovecii pneumonia DUNA Yan, XU Yuan, YANG Changqing, ZHANG Jinping Chinese Journal of Mycology    2023, 18 (1): 1-7.   Abstract （167）      PDF （2630KB）（160）       Knowledge map    Save Objective To systematically evaluate the efficacy and safety of trimethoprim-sulfamethoxazole (TMP/SMZ) combined with caspofungin in the treatment of Pneumocystis jirovecii pneumonia (PJP). Methods PubMed, Embase, Cochrane library, CBM, CNKI, Wanfang, VIP were searched for clinical randomized controlled trials of TMP/SMZ combined with caspofungin in the treatment of PJP, and Meta-analysis was performed. The outcome indicators were total effective rate, incidence of adverse reactions Statistical analysis was performed using RevMan 5.4 software. Results A total of 20 studies were included, involving 1 802 PJP patients. Meta-analysis results showed that compared with TMP/SMZ monotherapy, the effective rate of TMP/SMZ combined with caspofungin in the treatment of PJP was significantly improved, [RR =1.29, 95% CI (1.22,1.37),P< 0.00001], and no Increase the incidence of adverse drug reactions [RR =0.91,95% CI(0.79, 1.05),P=0.21>0.05]. Conclusion The effect of TMP/SMZ combined with caspofungin in the treatment of PJP is better than that of TMP/SMZ monotherapy, without increasing adverse drug reactions, and it is recommended for clinical use. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2022, 17 (4): 339-348.   Abstract （37）      PDF （1000KB）（157）       Knowledge map    Save Reference | Related Articles | Metrics

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Retrospective analysis of Kodamaea ohmeri infection in Asia from 2002 to 2022 ZHU Xinlin, LI Chen, HU Dongying, CHEN Xianzhen, JIANG Weiwei, LIU Yinuo, CHEN Tianyang, CHEN Tiancheng, LIAO Wanqing, LIU Xiaogang, PAN Weihua Chinese Journal of Mycology    2023, 18 (2): 123-129.   Abstract （84）      PDF （849KB）（150）       Knowledge map    Save Objective To analyze epidemiological trends and clinical characteristics of cases caused by Kodamaea ohmeri in Asia, and to provide a scientific basis for improving the clinical diagnosis and treatment of K. ohmeri infections. Methods Using the methods of literature review and meta-analysis to analyze retrospectively the information of patient’s nationality, sex and aged composition, risk factors, onset organs, clinical manifestations, therapeutic methods and prognosis of K. ohmeri. Results K. ohmeri infections could occur in both immunocompetent and immunocompromised person. The gender ratio of the infection host was 1.59:1, predominantly in premature neonate and middle aged people, and the blood system was the most commonly affected site. More than half of the patients had immunodeficiency diseases or other risk factors, and there were no early specific symptom with chief complaints of fever. Diagnosis of K. ohmeri infections mainly relied on culture. The patients had a poor prognosis, with high mortality. Conclusion The incidence of K. ohmeri infections has increased recently and the diagnosis mainly depends on culture. Strengthening the in vitro antifungal susceptibility monitoring and the studying of epidemiology for K. ohmeri are significant to improve the diagnosis and prognosis of K. ohmeri infections. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2022, 17 (4): 335-338.   Abstract （52）      PDF （825KB）（145）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2022, 17 (3): 247-250.   Abstract （41）      PDF （1179KB）（145）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2021, 16 (3): 188-193,210.   Abstract （283）      PDF （806KB）（145）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (1): 38-41.   Abstract （113）      PDF （813KB）（134）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2022, 17 (2): 173-176.   Abstract （30）      PDF （779KB）（132）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (2): 178-182.   Abstract （67）      PDF （809KB）（125）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2021, 16 (3): 211-216.   Abstract （229）      PDF （764KB）（123）       Knowledge map    Save Reference | Related Articles | Metrics

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Efficacy and safety of Meifute® antifungal solution combined with Feijia® antifungal solution in the treatment of onychomycosis XU Xiaoguang, YIN Jiankai, LIU Zhu, ZHENG Rui, LIU Weida, WEN Hai Chinese Journal of Mycology    2023, 18 (1): 42-46.   Abstract （398）      PDF （1256KB）（121）       Knowledge map    Save Objective To evaluate the efficacy and safety of Meifute® antifungal solution combined with Feijia® antifungal solution in the treatment of onychomycosis. Methods From December 2020 to November 2022, 120 patients were enrolled in Fumei Outpatient Departments for this study. First of all, a single-session soak in Meifute® antifungal solution was used to treat tinea pedis; and then, diseased nails were treated with Feijia® antifungal solution once a week for 28 weeks routinely; finally, another time of Meifute® antifungal solution treatment was given to consolidate the effect. Efficacy and safety evaluation was performed after treatment, and a questionnaire survey of treatment satisfaction was carried out after the completion of the treatment course. Results Finally 112 patients completed the study and 588 nails were included. Efficacy and satisfaction:overall effective rate was 58.0% (341/588), the cure rate was 20.6% (121/588), and the comprehensive satisfactory rate was 93.8% (105/112). The efficacy of the first toenail (52.9%) was lower than that of other toenails (60.7%). And there was no significant difference in the clinical response rate between DLSO (56.6%) and TDO (61.4%). Safety:The adverse reactions were all local symptoms, such as subungual hemorrhage (2 cases), exfoliation of epidermis around nails (4 cases), mild redness and swelling of skin (6 cases), mild to moderate burning or tingling (16 cases) after soak. All patients could tolerate the process without serious adverse reactions. Conclusion The use of Meifute® antifungal solution combined with Feijia® antifungal solution is simple, effective, safe, and highly compliant in the treatment of onychomycosis, so it can be regarded as a clinical alternative treatment for onychomycosis. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (1): 90-96.   Abstract （100）      PDF （917KB）（120）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2022, 17 (3): 251-254.   Abstract （38）      PDF （960KB）（115）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (1): 80-85.   Abstract （81）      PDF （1217KB）（108）       Knowledge map    Save Reference | Related Articles | Metrics

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In vitro susceptibility of berberine combined with antifungal agents against Talaromyces marneffei ZHANG Xinyu, PAN Kaisu, LUO Hong, ZHENG Dongyan, ZHENG Yanqin, CAO Cunwei, LIANG Gang Chinese Journal of Mycology    2021, 16 (3): 176-181.   Abstract （210）      PDF （1183KB）（106）       Knowledge map    Save Objective To investigate the effect of berberine alone or in combination with conventional antifungal drugs on Talaromyces marneffei yeast. Methods Twenty-one isolates of T. marneffei were assayed. Drug interactions were assessed with the chequerboard technique using the CLSI microdilution method (M27-A3) with minor modifications. The fractional inhibitory concentration index (FICI) was used to classify drug interactions. Time-kill curves were used to confirm the synergistic interaction. Results Berberine/voriconazole and berberine/amphotericin B combination showed the highest percentage of synergic interaction (71.4%); followed by berberine/itraconazole (66.67%), berberine/fluconazole (47.62%), berberine/caspofungin (52.38%), respectively. Time-kill curves confirmed the synergistic interaction, no antagonistic or indifferent action was observed. Conclusions In vitro berberine could enhances the efficacy of antifungal agents against the yeast form of T. marneffei. The MIC value can be greatly reduced when combined with conventional antifungal drugs. The results indicated berberine might have a potential role in combination with antifungal agents in freating patients infected with T. marneffei. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2022, 17 (3): 260-264.   Abstract （35）      PDF （982KB）（103）       Knowledge map    Save Reference | Related Articles | Metrics

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A case of Chromoblastomycosis caused by Fonsecaea monophora in Hainan fisherman NIU Mu, LIAO Wanqing, WU Weiwei, ZHENG Wenai Chinese Journal of Mycology    2021, 16 (3): 184-187.   Abstract （173）      PDF （1364KB）（99）       Knowledge map    Save Here we report a case of chromoblastomycosis caused by Fonsecaea momophora. A 80-year-old man was admitted to the hospital with a more than eleven years’s history of plaque on the right hand. Direct microscopic examination and fungal culture, histopathologic examination, ribosomal internal transcribed spacer (ITS) sequence analysis were performed. The thick-walled, brown sclerotic bodies were observed by direct microscopic examination and histopathological examination. Fungal culture yielded black brown villiform colonies and rhinocladiella type and cladosporium type conidia were observed in the slide culture. The isolate was identified as Fonsecaea momophora according to the ITS sequencing. The patient was prescribled itraconazole(200 mg/d) combined with terbinafine (250 mg/d) for 4 months.The lesions improved greatly and the patient was now under followed-up. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2021, 16 (3): 194-195.   Abstract （103）      PDF （1044KB）（97）       Knowledge map    Save Reference | Related Articles | Metrics

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A 3 days dose-escalation method for the administration of amphotericin B for childhood acute leukemia with invasive fungal disease LIU Yingting, CAO Lizhi, WANG Dan, YANG Minghua Chinese Journal of Mycology    2021, 16 (3): 170-175.   Abstract （286）      PDF （739KB）（96）       Knowledge map    Save Objective To evaluate the efficacy and safety of 3-day rapid dose escalation treatment of amphotericin B(AmB) in childhood acute leukemia(AL) patients with invasive fungal disease(IFD). Methods Data on 108 AL patients with IFD during March 2009 to December 2018 were collected. Those assigned to standard group (n=50) received standard treatment for 5 days. New Group (n=58) received rapid dose-escalation for 3 days, The rate of adverse events and overall success rate in 4 weeks after initiation of AmB therapy were documented and retrospectively analyzed. Results We found the overall success rate was differed significantly between patients with proven and probable fungal infections in two group and the incidence of adverse events was similar between all patients (54.5% vs. 80.5%,P=0.021). Conclusions The 3-day schedule for drug administration of AMB presented a more effective, with less toxicity than the standard approach to treatmentfor childhood acute leukemia patients with IFD. There is nosignificant difference in the rate of AES between the 3-day escalation strategy and the 6-day escalation strategy. So we concluded that three-day dose escalation was better than standard treatment. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2022, 17 (4): 324-329.   Abstract （40）      PDF （868KB）（94）       Knowledge map    Save Reference | Related Articles | Metrics

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Clinical analysis of 4 cases of disseminated fusariosis with hematological malignancies treated by hematopoietic stem cell transplantation and literature review CHENG Haoyu, LI Tingting, ZHANG Shuqin, GU Jiangying, XUE Song, ZHANG Weijie, WANG Wenjing, FEI Xinhong, YIN Yuming, WANG Jingbo Chinese Journal of Mycology    2021, 16 (3): 150-154.   Abstract （244）      PDF （1489KB）（93）       Knowledge map    Save Objective To improve the understanding of fusariosis, especially disseminated fusariosis, in patients with hematopoietic stem cell transplantation, so as to achieve early diagnosis and timely treatment, and improve the prognosis. Methods To retrospectively analyze the diagnosis, treatment and prognosis of 4 cases of hematopoietic stem cell transplant patients with disseminated fusariosis treated in our hospital, from April 2015 to September 2020. Results All the 4 patients were confirmed cases that occurred before hematopoietic stem cell implantation or neutrophilic phase, and received amphotericin B liposome combined with voriconazole. Disseminated fusariosis was controlled in 3 patients, and one patient died after treatment. Conclusion Disseminated fusariosis after hematopoietic stem cell transplantation had poor prognosis and high mortality. Effective antifungal therapy and rapid immune reconstruction in early stage were effective means to improve the survival. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2022, 17 (3): 231-234.   Abstract （29）      PDF （951KB）（92）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (1): 53-57.   Abstract （81）      PDF （853KB）（89）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (3): 285-288.   Abstract （71）      PDF （838KB）（88）       Knowledge map    Save Reference | Related Articles | Metrics

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Analysis of clinical characteristics and risk factors of nosocomial fungal urinary tract infection in ICU ZHU Junfeng, ZHOU Ziyang, HU Wangchao, TANG Jianguo Chinese Journal of Mycology    2022, 17 (4): 273-277.   Abstract （44）      PDF （1043KB）（88）       Knowledge map    Save Objective To investigate the clinical characteristics and risk factors of nosocomial fungal urinary tract infection in ICU. Methods The clinical data of patients with fungal urinary tract infection in the ICU of Shanghai Fifth People's Hospital affiliated to Fudan University from January 2016 to December 2020 were retrospectively analyzed, and the clinical characteristics and risk factors of the patients were described. Results ①From 2016 to 2020, a total of 2557 patients were enrolled in the intensive care unit of Shanghai Fifth People's Hospital Affiliated to Fudan University, and 130 patients met the research conditions. The incidence of fungal urinary tract infection was 5.1%. ②The clinical manifestations of nosocomial fungal urinary tract infection in ICU were atypical, and its occurrence was related to gender, age, and catheter indwelling time, but not to the year.③In the urine culture, Candida albicans was the main pathogen, accounting for 42.5%, followed by Candida glabra (31.3%), Candida tropicalis (19.4), Candida parapsilosis (4.5%), and other Candida (2.2%).④The risk factors of nosocomial fungal urinary tract infection in ICU were analyzed. Univariate analysis showed that diabetes, primary disease stroke, antibiotics, preinfection white blood cell count and preinfection enema had statistical significance (P<0.05).The significant indicators from univariate analysis were incorporated into the multivariate analysis. The Results showed that diabetes mellitus (P<0.001,OR=5.488), primary disease stroke (P=0.009,OR=2.782), preinfection white blood cell count (P=0.014,OR=3.515) and preinfection enema (P=0.001,OR=3.567) were independent risk factors for nosocomial fungal urinary tract infection in ICU. Conclusion For the nosocomial fungal urinary tract infection in ICU, we should take active measures to treat the primary disease and the basic disease, and at the same time, we should be alert to the enterogenous pollution caused by enema. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (1): 75-79.   Abstract （70）      PDF （840KB）（86）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (3): 270-272,281.   Abstract （45）      PDF （905KB）（85）       Knowledge map    Save Reference | Related Articles | Metrics

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Distribution of Malassezia species on the face of patients with atopic dermatitis of head and neck LIN Jie, YANG Lianjuan, YANG Mingzhen Chinese Journal of Mycology    2021, 16 (3): 161-165.   Abstract （227）      PDF （946KB）（81）       Knowledge map    Save Objective To investigate the distribution of Malassezia in patients with head and neck atopic dermatitis(AD) and its relationship with severity. Methods From September to December, 2020, 45 AD patients and 50 healthy volunteers were recruited. Scale samples were taken from the lesion and non-lesion areas on the face both of patients and volunteers with sterile cotton swabs, and the number of copies of 7 species of Malassezia were detected by quantitative real-time PCR. The species distribution and number were analyzed by using cross-sectional analysis. Results For head and neck AD patients,the Malassezia restricta and Malassezia globosa in the facial lesions were 3.13 times (P<0.05) and 6.69 times (P<0.05) of the healthy volunteers, respectively. Both of them were correlated with the severity of AD (P<0.05). Conclusion Malassezia restricta and Malassezia globosa of lesion areas on the face were more in head and neck AD patients than that in healthy people, and their levels were correlated with the severity of the disease. Reference | Related Articles | Metrics

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Distribution of pathogenic yeast species of vulvovaginitis and its epidemiological characteristics ZHOU Yihua, DENG Shuwen, ZHANG Lu, ZHANG Hong, ZHAO Rongfen, WANG Yufeng, SUN Yanxia, ZHU Hui Chinese Journal of Mycology    2023, 18 (1): 12-18.   Abstract （140）      PDF （1033KB）（80）       Knowledge map    Save Objective To investigate the epidemiological characteristics of vulvovaginitis caused by different yeast spp. Methods Totally 1 083 yeast isolates were collected from patients with vulvovaginal candidiasis (VVC). These isolates were identified to the species level according to the genes of 26S rRNA D1/D2 domain. The clinical characteristics VVC cases caused by these different species were analyzed. Results The results showed that Candida albicans remain the prodominent species(71.38%) causing VVC, while Non-candida albicans (NAC) account for 28.62% among which C.glabrata account for 19.02%. The risk factors included 20-40 years of age, being married,and pregnancy. NACs were more often isolated in pregnant women. The incidence of recurrent vaginal candidiasis caused by non-albicans Candida were higher. Conclusion Routine culture of secretion from VVC patients, molecular identification to species level of VVC causative agents, and identification of non-albicans Candida species would help clinicians to explore an effective therapy for VVC. Reference | Related Articles | Metrics