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Guidelinesforthe diagnosis andtreatment oftinea corporis andtinea crurisin China The Working Group on Guidelinesforthe Diagnosis and Treatment of Tinea corporis and Tinea Crurisin China Chinese Journal of Mycology    2023, 18 (3): 193-197.   Abstract （273）      PDF （740KB）（470）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (3): 265-269.   Abstract （67）      PDF （884KB）（222）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (3): 285-288.   Abstract （71）      PDF （838KB）（88）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (3): 270-272,281.   Abstract （45）      PDF （905KB）（85）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (3): 282-284.   Abstract （49）      PDF （814KB）（59）       Knowledge map    Save Reference | Related Articles | Metrics

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Pathogenic distribution characteristics of fungal bloodstream infection in Sichuan Province from 2019 to 2021 DENG Jin, YIN Lin, JIANG Haiyan, KUANG Linghan, PENG Xi, YANG Xianggui, NI Sujiao, ZHANG Bangqin, FENG Jinfang, WANG Yanling, MA Yushan, CHEN Zongyao, ZHONG Hanyu, WU Xianli, LI Kun, WANG Ling, GAO Wei, YANG Xueqiang, ZHU Jun, CHEN Yu, ZHANG Xian, SUN Changjun, LUO Jun, LI Yumei, LI Yan, ZHANG Bin, XIE Ning, WANG Jun, XIE Yi, KANG Mei Chinese Journal of Mycology    2023, 18 (3): 198-204,210.   Abstract （133）      PDF （1214KB）（55）       Knowledge map    Save Objective To collect the fungal bloodstream infection data from the Sichuan Provincial Center of China Fungal Disease Surveillance System, to analyze the distribution characteristics and the susceptibility to antifungal drugs of pathogens, and to provide epidemiological data for fungal bloodstream infections in Sichuan Province. Methods The data of outpatient, emergency, and inpatient fungal bloodstream infections in 28 hospitals from January 1, 2019, to December 31, 2021, were studied. The clinical and laboratory data of fungal bloodstream infection were analyzed using Whonet 5.6 and Microsoft Excle pivot table. information. Results From January 1, 2019, to December 31, 2021, Candida accounted for 88.8% (1083/1 220) of the 1 220 fungal strains was reported by 28 hospitals. Candida albicans was the main species, accounting for 35.3% (431/1 220).and Cryptococcus neoformans being fifth in the total number of isolates, accounting for 8.3% (101/1 220). Males accounted for 56.6% (690/1 220), and female patients were less (43.4%, 530/1 220); 79.8% cases were middle-aged and elderly patients (>46 years old) and 34.8% cases were from the intensive care unit. C. albicans had the highest sensitivity to fluconazole (85.7%); resistance rates of C.tropicalis to fluconazole and voriconazole were 43.4% and 43.3%, respectively. by C. albicans isolates were dominated in Most hospitals, however, C. parapsilosis was mostly isolated in children's specialized hospitals. Conclusion The pathogens of fungal bloodstream infection and their antifungal drug susceptibility have regional characteristics. Accurately grasping the epidemiological data in the region can provide a basis for the clinical selection of antifungal drugs. Reference | Related Articles | Metrics

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Pathogenic distribution andriskfactor analysis of COPD patients with secondary pulmonaryfungalinfections ZHANG Peiyun, DUN Jun, LUO Xinyue, HENG Xin, WANG Songping Chinese Journal of Mycology    2023, 18 (3): 232-235,245.   Abstract （97）      PDF （875KB）（55）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (3): 276-281.   Abstract （51）      PDF （895KB）（52）       Knowledge map    Save Reference | Related Articles | Metrics

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Two cases of pulmonary cryptococcosis diagnosed by metagenomic next-generation sequencing YU Ke, WU Lili, HUANG He, ZHANG Min, DENG Haiyan Chinese Journal of Mycology    2023, 18 (3): 241-245.   Abstract （91）      PDF （2169KB）（45）       Knowledge map    Save Pulmonary cryptococcosis is one of the most common pulmonary fungal infections. It lacks clinical and imaging specificity and is easy to be misdiagnosed and missed. The diagnosis of pulmonary cryptococcosis mostly depends on etiology and histopathology. The metagenomic next-generation sequencing technology that has emerged in recent years provides new ideas for the early and rapid diagnosis and treatment of infectious diseases. This article reports the clinical characteristics and the process of diagnosis and treatment of 2 cases of pulmonary cryptococcosis patients, with no previous immunocompromised diseases and no complaining of respiratory symptoms. Physical examination found no obvious signs, chest computed tomography (CT) scan showed a round solid nodules in the outer area of the lung field. They were finally diagnosed rapidly by the the metagenomic next-generation sequencing(mNGS) technology of bronchoalveolar lavage fluid and received treatment on time. Reference | Related Articles | Metrics

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mNGS-assisted diagnosis ofcutaneousinfectious granuloma caused byfungi YANG Qiuhong, HUANG Xin, YUAN Xiaoying Chinese Journal of Mycology    2023, 18 (3): 226-228,231.   Abstract （60）      PDF （1935KB）（43）       Knowledge map    Save Reference | Related Articles | Metrics

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A case of Prototheca wickerhamii infection in lower limbs ZHAO Yue, LING Yong, OUYANG Feng, QUE Manfang Chinese Journal of Mycology    2023, 18 (3): 254-256,260.   Abstract （85）      PDF （1607KB）（41）       Knowledge map    Save A 39-year-old man was found to have reduced blood cells during physical examination 8 years ago. Cyclosporine and prednisone were taken for a long time, after undergoing bone marrow, flow cytometry and other examinations to diagnose paroxysmal nocturnal hemoglobinuria (PNH). More than 2 months ago,his left lower extremity was scratched, accompanied by ulceration, redness, swelling and pain. Recently he had been admitted to the hospital and immune indicators were reduced, accompanying by secondary hyperglycemia. Wound tissues and secretions were taken for pathological examination and pathogenic testing. Piperacillin/tazobactam was used for empirical anti-infective therapy. After being diagnosed with Prototheca wickerhamii infection, the antibiotic was replaced by amphotericin B according to antimicrobial susceptibility testing. The dosage of the 1st day was 1 mg, the 2nd to 4th days were 10mg and 5th-10th days were 25 mg once a day. Due to elevated creatinine,the dosage was reduced to 15 mg every other day and wound care was performed at the same time. At last, there was no obvious inflammatory secretion and the wound had healed, when re-examining one month later. Reference | Related Articles | Metrics

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Analysis of clinical features and death-related risk factors of Candida bloodstream infection YANG Yang, ZHANG Xiaoli, WANGJianmin, GONG Xue Chinese Journal of Mycology    2023, 18 (3): 221-225.   Abstract （115）      PDF （848KB）（38）       Knowledge map    Save Objective To explore the clinical features of Candida bloodstream infection. Methods The clinical data of 62 patients diagnosed with Candida bloodstream infection in our hospital from January 2017 to December 2021 were collected, and the distribution of pathogen, clinical characteristics and risk factors of death were analyzed. Results A total of 65 strains of fungi were isolated from 62 patients with Candida bloodstream infection, mainly distributed in the intensive care unit (33 strains), urology (7 strains) and hematology (6 strains) departments; the strains were Candida albicans (29.2%), Candida glabrata (26.2%), Candida parapsilosis (21.5%), and Candida tropicalis (18.5%), and the overall non-susceptibility rate to fluconazole was 38.5%. Among 62 patients with Candida bloodstream infection 34 died, and the mortality rate was 54.8%; Univariate analysis showed that admission to intensive care unit, mechanical ventilation, combined lung infection, severe hypoalbuminemia, and no antifungal therapy within 48 hours after positive blood culture were associated with mortality (P<0.05). Logistic regression analysis showed that severe hypoalbuminemia(OR=7.924,95% CI 1.851~34.599,P=0.006) and failure to initiate antifungal therapy within 48 hours after the initial blood culture report(OR=6.828,95% CI 1.377~33.852,P=0.019) were independent risk factors for death. Non-albicans Candida infection was the main, and severe hypoalbuminemia was an independent risk factor for death in patients with Candida bloodstream infection. Early antifungal therapy was important for patient prognosis. Conclusion Candida bloodstream infection patients were characterized by multiple comorbidities and high mortality. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (3): 273-275.   Abstract （54）      PDF （808KB）（37）       Knowledge map    Save Reference | Related Articles | Metrics

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Analysis of pathogen distribution pattern and clinical features of 124 cases of otomycosis in Guangzhou XIANGJieying, XU Zhiping, WANG Rong, XU Jianrong, XIE Zhenmou, XUE Yaohua Chinese Journal of Mycology    2023, 18 (3): 211-215.   Abstract （98）      PDF （840KB）（36）       Knowledge map    Save Objective To analyze the clinical characteristics and pathogen distribution of 124 cases of otomycosis in Guangzhou. Methods The clinical data of one hundred and twenty-four patients diagnosed with otomycosis and positive fungal cultures from the otorhinolaryngology department of Guangzhou First People's Hospital between January 2020 to January 2022 were retrospectively analyzed. Results The 124 patients were mainly 18-40 years old (78/124, 62.9%). Unclean ear picking (55/124, 44.4%) and frequent use of earphones (45/124, 36.3%) were the main factors for causing otomycosis. The most common clinical feature was pruritus (96/124, 77.4%), followed by fluid/pus, hearing loss, pain and tinnitus. A total of 94 strains of Aspergillus (94/124, 75.81%) were isolated, including 37 strains of Aspergillus terreus (29.8%) and 34 strains of Aspergillus niger(27.4%). Moreover, 19 strains of Candida (15.3%), 5 strains of Penicillium (4.0%), 5 strains of Malassezia (4.0%) and 1 strain of Trichophyton rubrum (0.8%) were isolated. Unclean ear picking was positively correlated with Aspergillus infection (P<0.05), hearing loss and pain were positively correlated with Aspergillus infection (P<0.05), and ear canal pruritus was positively correlated with Candida infection (P<0.05). Conclusion Aspergillus and Candida were the main fungal pathogens of otomycosis, and Malassezia was the opportunistic pathogen of otomycosis. There was an association of clinical features with pathogen distribution pattern,which should be caused by clinical attention. Reference | Related Articles | Metrics

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A case of chromoblastomycosis caused by Fonsecaea monophora MA Shanshan, LI Jin, LU Weiping, HUANG Qing, LEI Xia, LI Min Chinese Journal of Mycology    2023, 18 (3): 250-253.   Abstract （58）      PDF （2039KB）（35）       Knowledge map    Save To report a case of chromoblastomycosis caused by Fonsecaea monophora in Chongqing. An 81-year-old male patient came to our hospital with ulcer and pain for more than one year after the skin on the inner side of his left upper arm was cut by an iron piece. Histopathological examination and fungal culture were performed on the skin lesions of the patients, and the cultured colonies were identified by morphology and molecular biology methods. Colony morphology: dark brown and black colonies were observed. Microscopically, cladosporium and rostrum sporulation were observed. Histopathological examination of the lesions showed chronic granulomatous changes. Sequencing of the internal transcribed spacer (ITS) region was identified as Fonsecaea monophora. According to the laboratory culture results and clinical data analysis, this case was identified as chromoblastomycosis caused by Fonsecaea monophora. Oral itraconazole 200mg twice a day, combined with drug application topically and photodynamic therapy was effective. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (3): 257-260.   Abstract （47）      PDF （828KB）（29）       Knowledge map    Save Reference | Related Articles | Metrics

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Talaromyces marneffei infection in a suspected healthy host: a case report and literature review LIU Huanjun, GUO Shuxia, WANG Yanmei, XU Xiaoyan Chinese Journal of Mycology    2023, 18 (3): 236-240.   Abstract （58）      PDF （1525KB）（27）       Knowledge map    Save A 28-year-old male patient was admitted to the hospital because of "half a month of abdominal pain". After a week of anti-infection treatment at the local clinic, he was transferred to our hospital. Physical examination revealed that several enlarged lymph nodes could be palpable bilaterally in the subjaw, subchin and neck, with a maximum of 30mm×30mm, toughness, smooth surface and good range of motion. There was no rash. Auscultation of the heart and lungs was normal. The abdominal wall was tough, the middle and upper abdomen was tender. There was no rebound pain and muscle tension, the mass could be touched, located in the left middle and upper abdomen, the maximum was about 60mm×40mm, not easy to move. The liver and spleen were not touched under the ribs. Bowel sounds were normal, and there was no edema in both lower limbs. Lymph node biopsy, next generation sequencing (NGS) and other related examinations were completed to confirm the diagnosis of Talaromyces marneffei infection. Amphotericin B was micropumped for nearly half a month, and then voriconazole was used intravenously for half a month. After discharge, oral voriconazole was continued for 2 months. The immune function of the patient was normal and there was no underlying disease. Three months later, the patient reexamined and the results showed that there was no swelling of the superficial lymph nodes. The abdomen was soft, without tenderness, rebound pain and muscle tension, and no abdominal mass was touched. Abdominal CT showed that the lymph nodes were reduced and the range was reduced. The condition improved significantly and was under follow-up. Reference | Related Articles | Metrics

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Bloodstream infection caused by Prototheca wickerhamii:a case report and review of the literatures ZHANG Xu, LI Chen, PAN Juan, LI Zuyi, NIE Ge Chinese Journal of Mycology    2023, 18 (3): 246-249,253.   Abstract （99）      PDF （1603KB）（26）       Knowledge map    Save A 44-year-old male farmer presented with erythematous plaques of the whole body, diffusely infiltrated erosions on his left leg and fever. Smooth, creamy-white, yeast-like colonies grew from skin biopsy specimen and blood specimen after 72 h of incubation. Electron microscopy demonstrated 'morula' or daisy-like appearance of its endosporulating sporangia. These findings were consistent with a diagnosis of protothecosis. The patient was treated with fluconazole and itraconazole but finally died. This case and the literature review will increase the knowledge of this pathogen. Reference | Related Articles | Metrics

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Diagnostic value of quantitative real-time PCR in bronchoalveolar lavage fluid for HIV-negative talaromycosis marneffei LIAO Liuwei, PAN Kaisu, LI Bingkun, ZHENG Dongyan, CAO Cunwei, ZHENG Yanqing Chinese Journal of Mycology    2023, 18 (3): 205-210.   Abstract （133）      PDF （877KB）（23）       Knowledge map    Save Objective To determine the loads of Talaromyces marneffei (TM) in bronchoalveolar lavage fluid (BALF) of the patients with non-HIV-infected talaromycosis marneffei (TSM) by quantitative real-time PCR (qPCR) and to evaluate the diagnostic value of it. Methods A total of 17 cases of non-HIV-infected TSM patients with pulmonary infection symptoms and 33 cases of patients with other fungal infections in the lung or non-infected patients were collected from The First Affiliated Hospital of Guangxi Medical University from September 2019 to June 2022. Samples of blood and BALF were collected from every patient at the same time. Extracting DNA from their BALF and serum, and then using qPCR to measure the loads of TM in these samples. Fungal culture of BALF was performed at the same time. Results In 17 cases of TSM, only 11.8% (2/17) of these cases were positive for qPCR measured in serum, but the positive rate of BALF qPCR was 90.0% (9/10) in patients with positive BALF fungal culture. Besides, there were 2 cases with positive BALF qPCR test results but with negative fungal culture of TM using the same sample. All the serum and BALF qPCR of other fungal infections in the lung or non-infected patients in this study were negative. In the TSM group, the median Cq value for BALF qPCR detection was 31.40 cycles (range 20.71-35.59). The qPCR showed a substantial agreement with the gold standard (kappa:0.708) and superiority to the fungal culture (kappa: 0.653) and directly microscopy-examined (kappa: 0.220). Conclusion This study showed that using qPCR to measure the loads of TM in BALF could have a high value in the early diagnosis of non-HIV-infected TSM patients with pulmonary infection symptoms. Reference | Related Articles | Metrics

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Direct microscopy of fluid aspirated from bursa or joint is helpful for early diagnosis of protothecal bursitis or protothecal arthritis XIE Xinzhe, LU Sha, CAI Wenying, ZHANGJunmin, LI Jiahao, LIN Li, XI Liyan Chinese Journal of Mycology    2023, 18 (3): 216-220.   Abstract （66）      PDF （1740KB）（22）       Knowledge map    Save Objective To investigate the early diagnosis value and clinical application of direct microscopy of fluid aspirated from bursa or joint for diagnosing protothecal bursitis or protothecal arthritis. Methods In this paper, we reported a case of Prototheca wickerhamii infective interdigital arthritis admitted in our department in March 2022, and then we reviewed the literatures about protothecal bursitis or protothecal arthritison published in PubMed, CNKI and Wanfang Database from January 1, 1964 to May 31,2022. We analyzed the main etiological examination methods in different patients and the early diagnostic value of direct microscopy of fluid aspirated from bursa or joint. Results After selection, 18 articles (21 cases) conforming to the aim of the study were included. The main etiological examination methods included fungal culture and histologic examination, while fungal direct microscopy was often ignored.Among the 22 patients, only 2 patients underwent both direct microscopy and fungal culture, 18 patients underwent fungal culture without direct microscopy, and the remaining 2 patients were diagnosed by histologic examination without direct microscopy and fungal culture. Conclusions Direct microscopy of fluid aspirated from bursa or joint is helpful for early diagnosis of protothecal bursitis or protothecal arthritis.It deserves attention and promotion caused it lacks properly clinical application. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (3): 261-264.   Abstract （46）      PDF （846KB）（22）       Knowledge map    Save Reference | Related Articles | Metrics

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Comparison offungalfluorescence staining and PASstaininginthe diagnosis of pulmonarycryptococcus PAN Lianlian, ZHU Chen, MEI Yong Chinese Journal of Mycology    2023, 18 (3): 229-231.   Abstract （59）      PDF （1214KB）（18）       Knowledge map    Save Reference | Related Articles | Metrics

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Treatment of postoperative Candida glabrata infection after total knee arthroplasty: a case report MENG Zhongjing, CAO Lulu, LU Jin, LIU Zhongqiu, ZHAN Guanjun Chinese Journal of Mycology    2023, 18 (4): 331-334.   Abstract （85）            Knowledge map    Save Periprosthetic fungal infection was a catastrophic complication after artificial joint replacement, and its diagnosis and treatment had always been one of the hot research topics in the field of orthopedics. A case of a 66-year-old immunocompetent man who underwent total knee arthroplasty and infected with Candida glabrata six years later with signs of prosthetic infection were reported. The pathogenic diagnosis and anti-fungal therapy might provide a reference for the drug treatment of periprosthetic fungal infection after artificial joint replacement. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (4): 381-384.   Abstract （112）            Knowledge map    Save Reference | Related Articles | Metrics

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Clinical characteristics of 20 cases of PJP and the value of NGS in the diagnosis of PJP GONG Yuan, SONG Xinyu Chinese Journal of Mycology    2023, 18 (4): 296-300.   Abstract （153）            Knowledge map    Save Objective To analyze the clinical features and high-risk factors of Pneumocystis jirovecii pneumonia (PJP), explore the value of metagenomic sequencing (mNGS) in the diagnosis of PJP, and seek possible prognostic indicators in PJP patients. Methods From April 2020 to December 2021, the clinical data of 20 PJP patients admitted to our department were collected, and their clinical characteristics were analyzed. The differences in laboratory indexes before and after treatment and the value of different detection methods in diagnosis were compared. Results Pneumocystis infection was detected by NGS in BALF of 20 patients, meanwhile, the positive rate of blood G test was 90%. However, neither smears nor cultures of the pathogen showed signs of pneumocystis infection. After anti-PJP treatment, 14 cases were clinically relieved, and the difference in peripheral blood lymphocyte. Conclusion Compared with the sensitivity of conventional etiological smears and cultures, mNGS showed better value in the diagnosis of PJP. NGS could identify pathogens with high sensitivity. In addition, peripheral blood lymphocytes were positively correlated with disease recovery and could be used as one of the laboratory markers of prognosis in PJP patients. Reference | Related Articles | Metrics

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Study on the effect of fluconazole with subinhibitory concentration on the virulence of Candida glabrata based on the Galleria mellonella infection model CHENG Peng, A Xiangren, ZHOU Jianwu, MU Xiaoming, TIAN Lijuan, MA Xiaoya Chinese Journal of Mycology    2023, 18 (4): 291-295.   Abstract （117）            Knowledge map    Save Objective Based on the Galleria mellonella infection model, the effect of sub-MIC fluconazole on the virulence of Candida glabrata was investigated. Methods Non repetitive Candida glabrata strains clinically isolated from Qinghai Provincial People’s Hospital from April 2021 to October 2022 were collected, and the minimum inhibitory concentration (MIC) of fluconazole against Candida glabrata was determined by ATB method. The virulence of Candida glabrata was tested by the Galleria mellonella infection model, and the success of the model was evaluated by pathological and pathogenic methods. Effects of puncture and different sub-MIC FLUs on healthy Galleria mellonella: the control group did not do any treatment, and the experimental group was divided into three groups, namely PBS group (10 μL PBS), FLU subgroup(inject 10 μL fluconazole solution respectively, making the FLU concentration in the body of infected Galleria mellonella 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 4 mg/kg, 8 mg/kg, and 16 mg/kg) and puncture group (micro syringe puncture but no injection). Use 2.50×106 yeasts /larva infected with Galleria mellonella, after 2 h, the control group was injected with 10 μL PBS, the experimental group was injected with different concentrations of FLU working solution, observing the therapeutic effect on the Galleria mellonella infected by Candida glabrata. Results The MIC of fluconazole to 9 clinically isolated Candida glabrata was 8 mg/L~32 mg/L, and that of Candida glabrata ATCC2001 was 32 mg/L. Yeast-like spores were detected in the pathological section of the intestinal tissue of the Galleria mellonell in the experimental group, and Candida glabra was cultured in the intestinal tissue.No fungus was found in the pathological section and fungal culture of the intestinal tissue in the control group. Puncture could cause damage to the Galleria mellonella, but the mortality was less than 10%. 1/2 MIC fluconazole could improve the survival rate of Candida glabrata infected Galleria mellonella with statistical significance(P<0.05),while 1/4 MIC, 1/8 MIC,1/16 MIC fluconazole had no significant intervention effect on the survival rates of Candida glabrata infected Galleria mellonella compared with PBS and the difference was not statistically significant (P>0.05). Conclusion 1/2 MIC fluconazole had inhibitory effect on the virulence of Candida glabrata, but the concentration below 1/2 MIC had no obvious protective effect. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (4): 327-330.   Abstract （69）            Knowledge map    Save Reference | Related Articles | Metrics

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Evaluation of clinical efficacy of Baihua lotion in combination with terbinafine cream for Keratinized ringworm Chinese Journal of Mycology    2023, 18 (4): 320-322,330.   Abstract （62）            Knowledge map    Save Reference | Related Articles | Metrics

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Rapid diagnosis of kerion in a child by dermoscopy and fungal fluorescence microscopy GUO Hengshan, ZHOU Xiulian, LIU Minhong, LIU Fangyan, LI Weiquan Chinese Journal of Mycology    2023, 18 (4): 335-336.   Abstract （68）            Knowledge map    Save Kerion is a fungal skin disease caused by the infection of Microspore genus,which can lead to a large area of cicatricial alopecia and affect the physical and mental health of patients. Early correct diagnosis is extremely important. Fungal pathogen detection is the main basis for the diagnosis of tinea capitis at present, but there is a certain false negative rate in fungal direct microscopic examination, and it takes a long time for fungal culture. One case of kerion in a child was diagnosed by dermatoscopy and fungal fluorescence staining. Fluconazole combined with glucocorticoid treatment was satisfactory. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (4): 370-376.   Abstract （164）            Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (4): 350-353.   Abstract （81）            Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (4): 359-363.   Abstract （70）            Knowledge map    Save Reference | Related Articles | Metrics

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Oral terbinafine and itraconazole combination therapy in the treatment of child kerion: a case report WANG Qing, LV Jing, DU Yu, HE Shudan, GU Yuzhi, LIU Juanjuan Chinese Journal of Mycology    2023, 18 (4): 337-339.   Abstract （75）            Knowledge map    Save A 10-year-old male patient presented with erythema,pustules and alopecia on the scalp with pain for more than 1 week. The fungal microscopic examination was positive, and Trichophyton mentagrophytes was suggested by fungal culture, The diagnosis of kerion was made.After being given terbinafine tablets combined with itraconazole capsules for antifungal and methylprednisolone anti-inflammatory treatment, the skin lesions were healed without scars, and the hair growth was normal. Reference | Related Articles | Metrics

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A case of chroniccutaneous mucormycosis caused by Mucor irregulari treated with conventional amphotericin B WANG Shiqi, SONG Yinggai, MO Ran, WAN Zhe, XU Yonghao, LI Ruoyu Chinese Journal of Mycology    2023, 18 (4): 347-349,353.   Abstract （70）            Knowledge map    Save The patient was a 44-year-old female with erythema and papules on her face for 16 years, ulcers and black crusts for 8 years. Dermatological examination: diffuse swelling erythema, large well-demarcated ulcers with necrotic eschar on her face. She presented bilateral eyelid ectropion and lost her sight of the right eye. The patient was diagnosed as chronic cutaneous mucormycosis caused by Mucor irregulari after direct microscopic examination, fungal culture and molecular identification. Intravenous amphotericin B was given. The lesions were significantly improved but left atrophic scar. Reference | Related Articles | Metrics

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Clinical characteristics of fungal ball sinusitis and it’s osteitis ZHONG Li, WANG Yongxin, LI Xinhua, LIU Jiying, XIAO Yi Chinese Journal of Mycology    2023, 18 (4): 315-319.   Abstract （76）            Knowledge map    Save Objective The aim of this study is to the clinical features of fungal spheroid fungal sinusitis and osteitis. Methods The clinical data of 105 FBS patients (110 sinuses in total) were retrospectively analyzed,the clinical features of their symptoms, signs, image, pathology, and osteitis were summarized and analyzed. Results Among the 110 sinuses, 97 sinuses (88.2%) were located in the maxillary sinus, and 13 sinuses (11.8%) were located in the sphenoid sinus; 97 sinuses (88.2%) had different degrees of bone thickening compared with the contralateral sinus. The wall bone of lesion sinus and contralateral sinus were significantly different in bone thickness (0.34±0.17 vs. 0.14±0.08), CT value (1161.5±322.5 vs. 864.2±482.8), GOSS score (3.0±1.4 vs. 0.3±0.9) .Pathological observation showed manifestations of osteomyelitis accompanied by bone remodeling activities. Conclusion Fungal spheroid fungal sinusitis prefer to occurs in the maxillary sinus and sphenoid sinus, mainly in single sinus. Most of the wall bone around the lesion sinuses have obvious osteitis, which is mainly characterized by bone thickening and increased CT value. Reference | Related Articles | Metrics

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A study on the distribution and the biofilm formation related genes of Candida parapsilosis complex clinically isolated in Guizhou area WANG Shun, LI Hong, QU Yujie, LI Tingting, JIN Tingting, HU Fangfang, LUO Zhenhua Chinese Journal of Mycology    2023, 18 (4): 301-309.   Abstract （104）            Knowledge map    Save Objective The distribution of infection and drug susceptibility characteristics of Candida parapsilosis complex strains were studied in Guizhou. Detection of the biofilm formation capacity of strains and the expression level of its CDC28 gene were performed. Methods The BACTECTM FX and Phoenix-100 instrument were used to identify the strains isolated in there tertiary first class hospitals in Guizhou from January 2017 to December 2019. The Candida parapsilosis complex group was identified by gene sequencing. ATB FUNGUS 3 kit was used to detect drug susceptibility of strains. The Candida parapsilosis biofilms formation capacitywas detected, and the expression levels of their CDC28 genes were detected using qRT-PCR. Results A total of 163 strains of Candida parapsilosis complex were isolated and identified, of which Candida parapsilosis type I, II and III accounted for 73.0%, 6.1% and 20.9% respectively. Urine and blood specimens got the most isolated strains (both 50 strains). Among the ioslates from infected bloodstream, type I, II and III accounted for 54.0%, 10.0% and 36.0% respectively. Three genotype strains were not significantly resistant to antifungal drugs. Among the 17 clinical strains, 16 (94.1%) had biofilm formation ability, of which 2, 4 and 10 strains had strong, general and weak biofilm formation capacity. CDC28 expressed upregulation in 2 strains with strong and 3 strains with general ability. Conclusion The isolated Candida parapsilosis complex was dominated by type I, and the three genotype strains were not obviously resistant to antifungal drugs. Different Candida parapsilosis showed different biofilm formation capacity, and the CDC28 gene might be associated with biofilm formation. Reference | Related Articles | Metrics

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Mechanisms of EREG incryptococcal traversal of the blood-brain barrier ZHAO Jingyu, LIU Yishu, DING Junli, GAO Yangjie, XU Lezhen, LIAO Wanqing, FANG Wei, GU Junlin Chinese Journal of Mycology    2023, 18 (4): 310-314.   Abstract （67）            Knowledge map    Save Objective To determine the expression level of EREG in the blood-brain barrier infected by Cryptococcus neoformans and to explore the role of EREG crossing the blood-brain barrier. Methods To construct the model of blood brain barrier in vitro by using Cryptococcus neoformans and Transwell chamber, and PBS was used as the control group. According to the time of Cryptococcus infection, divided into three groups: 3 h, 6 h and 12 h. The changes of the adhesion and penetration ability of Cryptococcus to the blood-brain barrier were detected by detecting the transmembrane resistance of single cells in the upper chamber of the Transwell and the suspension coating in the lower chamber of the Transwell at different time of infection, and the expression level of EREG in vascular endothelial cells during the process was detected. Results The expression of EREG was significantly increased and positively correlated with the time of infection during the course of cryptococcal infection with microvascular endothelial cells. Conclusion These results indicated that the ability of Cryptococcus to cross the blood-brain barrier was closely related to the expression level of EREG. Reference | Related Articles | Metrics

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A case of mixed bloodstream infection of Trichosporon asahii and Magnusiomyces clavatus in a patient with bone marrow transplantation LI Jixia, MIN Yan Chinese Journal of Mycology    2023, 18 (4): 340-343.   Abstract （50）            Knowledge map    Save A 40-year-old female patient with myelodysplastic syndrome had recurrent fever after bone marrow transplantation. Blood culture showed that the bloodstream was infected with 2 strains of fungi. 18S ribosomal RNA (18S rRNA) sequencing results showed that one of the fungi was Trichosporon assahii and the other was Magnusiomyces clavatus. The two fungi were rare fungi, both sensitive to voriconazole. Due to the long time of identification and drug sensitivity, the patient did not wait for the adjustment of reasonable antifungal drugs, and died due to persistent neutropenia and fungemia. This case was the first report in Chinese of bloodstream mixed infection of Trichosporon asahii and Magnusiomyces clavatus in patients with hematological diseases. Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (4): 377-380.   Abstract （78）            Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Mycology    2023, 18 (4): 364-369.   Abstract （40）            Knowledge map    Save Reference | Related Articles | Metrics