Abstract: To report a case of chromoblastomycosis caused by Fonsecaea monophora in Chongqing. An 81-year-old male patient came to our hospital with ulcer and pain for more than one year after the skin on the inner side of his left upper arm was cut by an iron piece. Histopathological examination and fungal culture were performed on the skin lesions of the patients, and the cultured colonies were identified by morphology and molecular biology methods. Colony morphology: dark brown and black colonies were observed. Microscopically, cladosporium and rostrum sporulation were observed. Histopathological examination of the lesions showed chronic granulomatous changes. Sequencing of the internal transcribed spacer (ITS) region was identified as Fonsecaea monophora. According to the laboratory culture results and clinical data analysis, this case was identified as chromoblastomycosis caused by Fonsecaea monophora. Oral itraconazole 200mg twice a day, combined with drug application topically and photodynamic therapy was effective.

Key words: Fonsecaea monophora, chromoblastomycosis, ITS region sequencing, itraconazole