Abstract: A 28-year-old male patient was admitted to the hospital because of "half a month of abdominal pain". After a week of anti-infection treatment at the local clinic, he was transferred to our hospital. Physical examination revealed that several enlarged lymph nodes could be palpable bilaterally in the subjaw, subchin and neck, with a maximum of 30mm×30mm, toughness, smooth surface and good range of motion. There was no rash. Auscultation of the heart and lungs was normal. The abdominal wall was tough, the middle and upper abdomen was tender. There was no rebound pain and muscle tension, the mass could be touched, located in the left middle and upper abdomen, the maximum was about 60mm×40mm, not easy to move. The liver and spleen were not touched under the ribs. Bowel sounds were normal, and there was no edema in both lower limbs. Lymph node biopsy, next generation sequencing (NGS) and other related examinations were completed to confirm the diagnosis of Talaromyces marneffei infection. Amphotericin B was micropumped for nearly half a month, and then voriconazole was used intravenously for half a month. After discharge, oral voriconazole was continued for 2 months. The immune function of the patient was normal and there was no underlying disease. Three months later, the patient reexamined and the results showed that there was no swelling of the superficial lymph nodes. The abdomen was soft, without tenderness, rebound pain and muscle tension, and no abdominal mass was touched. Abdominal CT showed that the lymph nodes were reduced and the range was reduced. The condition improved significantly and was under follow-up.

Key words: Talaromyces marneffei, a healthy host, lymph node