Clinical characteristics and risk factors for mortality of 94 patients with Candida bloodstream infection

Abstract

Abstract: Objective To investigate the clinical distribution of 94 patients with blood flow infection of Candida and the related risk factors of death. Methods The clinical characteristics and death risk factors of patients with blood flow infection of Candida diagnosed in Liuzhou People's Hospital from January 2019 to December 2021 were analyzed retrospectively. Results From 2019 to 2021, 94 cases of Candida were detected in blood flow infection patients, mainly distributed in ICU and surgery, accounting for 58.5%; The top three Candida species were C. albicans, C. tropicalis and C. parapsilosis, accounting for 48.9%, 16.0% and 13.8% respectively;33 of 94 patients with blood flow infection of Candida died, the mortality rate was 35.1%. C. albicans (57.6%, 19/33) was most frequently detected in the dead patients, mainly distributed in ICU (57.6%, 19/33). The sensitivity rate of C. parapsilosis to azoles was 100%, the resistance rate of C. albicans to triazoles was less than 7% and the resistance rate of C. glabrata and C. tropicalis was 20%~26.7%. Univariate analysis showed that age ≥60 years, ≥2 basic diseases, mechanical ventilation and endotracheal intubation were associated with mortality (P<0.05). Logistic binary regression analysis showed that mechanical ventilation was an independent risk factor associated with mortality in patients with Candidal blood flow infection. Conclusion The detection rate of C. albicans in Candidal blood flow infection was the highest. Mechanical ventilation was an independent risk factor for death in patients with blood flow infection of Candida.

Key words: Candida, bloodstream infection, clinical characteristics, risk factors for mortality, mechanical ventilation

CLC Number:

R519.3

ZHOU Tingting, QIN Renli, XU Qiuhong, LUO Liuchun. Clinical characteristics and risk factors for mortality of 94 patients with Candida bloodstream infection[J]. Chinese Journal of Mycology, 2023, 18(2): 130-134.

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