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Chinese Journal of Mycology 2023, Vol. 18  Issue (1): 42-46.

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Efficacy and safety of Meifute® antifungal solution combined with Feijia® antifungal solution in the treatment of onychomycosis

XU Xiaoguang1, YIN Jiankai2, LIU Zhu1, ZHENG Rui1, LIU Weida3, WEN Hai4   

  1. 1. Shanghai Fumei Dermatology Clinic, Shanghai 201107, China;
    2. Jiangyin Fumei Dermatology Clinic, Wuxi 214433, China;
    3. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China;
    4. Shanghai Changzheng Hospital, Shanghai 200003, China
  • Received:2023-02-02 Published:2023-03-17

Abstract: Objective To evaluate the efficacy and safety of Meifute® antifungal solution combined with Feijia® antifungal solution in the treatment of onychomycosis. Methods From December 2020 to November 2022, 120 patients were enrolled in Fumei Outpatient Departments for this study. First of all, a single-session soak in Meifute® antifungal solution was used to treat tinea pedis; and then, diseased nails were treated with Feijia® antifungal solution once a week for 28 weeks routinely; finally, another time of Meifute® antifungal solution treatment was given to consolidate the effect. Efficacy and safety evaluation was performed after treatment, and a questionnaire survey of treatment satisfaction was carried out after the completion of the treatment course. Results Finally 112 patients completed the study and 588 nails were included. Efficacy and satisfaction:overall effective rate was 58.0% (341/588), the cure rate was 20.6% (121/588), and the comprehensive satisfactory rate was 93.8% (105/112). The efficacy of the first toenail (52.9%) was lower than that of other toenails (60.7%). And there was no significant difference in the clinical response rate between DLSO (56.6%) and TDO (61.4%). Safety:The adverse reactions were all local symptoms, such as subungual hemorrhage (2 cases), exfoliation of epidermis around nails (4 cases), mild redness and swelling of skin (6 cases), mild to moderate burning or tingling (16 cases) after soak. All patients could tolerate the process without serious adverse reactions. Conclusion The use of Meifute® antifungal solution combined with Feijia® antifungal solution is simple, effective, safe, and highly compliant in the treatment of onychomycosis, so it can be regarded as a clinical alternative treatment for onychomycosis.

Key words: antifungal, onychomycosis, treatment

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