A retrospective analysis of cases caused by Rhodotorula mucilaginosa

Abstract

Abstract: Objective To analyze epidemiological and clinical characteristics of infections caused by Rhodotorula mucilaginosa, and to provide a scientific basis for improving the clinical diagnosis and treatment of R. mucilaginosa infections. Methods Using the methods of literature review and meta-analysis to analyze retrospectively the information of patient's nationality, sex and aged composition, risk factors, onset organs, diagnostic and therapeutic methods and prognosis of R. mucilaginosa worldwide in the past two decades. Results A total of 45 related literatures were included, including 60 cases of patients infected by R. mucilaginosa. R. mucilaginosa infections was most common in Europe. The gender ratio of the infection host was 1.68:1, predominantly in people aged 0-10 years and 40-50 years, and the blood system was the most commonly affected site. Most patients had underline diseases or other risk factors such as trauma and surgery, and there was no early specific symptom with chief complaints of fever. Diagnosis of R. mucilaginosa infections mainly relied on culture. The mortality rate was as high as 12.5%, except in patients with unknown prognosis. Conclusion The incidence of R. mucilaginosa infections has increased recently worldwide. The most commonly affected site was blood system, and the diagnosis mainly depends on culture. Strengthening the in vitro antifungal susceptibility monitoring and the studying of epidemiology for R. mucilaginosa are benefical to improve the clinical diagnosis and prognosis of R. mucilaginosa infections.

Key words: Rhodotorula mucilaginosa, epidemiology, clinical characteristics

CLC Number:

R519.8

ZHU Xinlin, LI Chen, HU Dongying, CHEN Xianzhen, CHEN Tianyang, CHEN Tiancheng, LIAO Wanqing, CHEN Min, PAN Weihua. A retrospective analysis of cases caused by Rhodotorula mucilaginosa[J]. Chinese Journal of Mycology, 2023, 18(1): 24-32.

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