Abstract: A 63-year-old male presented with a nodule on the left wrist for half a month. Physical examination showed hyperkeratotic plaques and nodule on the left wrist. Histopathological examination revealed a number of brown and roundish thick-walled sclerotic bodies in dermis and multinucleated giant cells. PAS staining was positive. Fungus culture test observed dark-brown to dark fungi which was confirmed as Fonsecaea monophora by sequencing. The patient was treated with oral itraconazole, but finally died of complications of silicosis.

Key words: chromoblastomycosis, Fonsecaea monophora, itraconazole