Subcutaneous phaeohyphomycosis caused by Microsphaeropsis arundinis：a case report and review of the literatures

Abstract

Abstract: A 80-year-old male farmer presented with invasive erythema on the right forearm for more than 1 year. He had 10-year history of Diabetes Mellitus. Dermatological examination revealed diffuse, invasive erythema on the right forearm, with warty hyperplasia, covered with black scab, skin damage area 5 cm×10 cm. Direct microscopic examination of the scurf and lesional tissue both showed branched hyphae.Culture showed grew dark gray, velvety colonies with grey-white edge on SDA. Microscopic morphology showed septate, irregularly shaped hyphae with oval, ellipsoidal conidia. Histopathological examination of the lesional tissue revealed Periodic-acid-Schiff (PAS)-positive spore-1ike structures. Sequencing analysis of the internal transcribed spacer (ITS) region revealed 100% consistence between the clinical isolate and reference strain of Microsphaeropsis arundinis. The patient was diagnosed with subcutaneous phaeohyphomycosis caused by M.arundinis. The patient was given itraconazole 400 mg daily orally. Five months later, the skin 1esions was noted to be improved. The patient was still under treatment and observation. The clinical characteristics of phaeohyphomycosis induced by M. arundinis were discussed by reviewing the literatures on infection caused by M. arundinis from 2000 to 2021.

Key words: Subcutaneous phaeohyphomycosis, Microsphaeropsis arundinis, diabetes mellitus

CLC Number:

YANG Hong, GAO Zhiqin, LIU Siyu, TAN Jingwen, XU Hong, CHEN Jian, YANG Lianjuan. Subcutaneous phaeohyphomycosis caused by Microsphaeropsis arundinis：a case report and review of the literatures[J]. Chinese Journal of Mycology, 2022, 17(3): 220-224.

References

[1] YANG H,CAI Q,GAO Z Q,et al. Subcutaneous phaeohyphomycosis caused by Exophiala oligosperma in an immunocompetent host:Case report and literature review[J]. Mycopathologia,2018,183(5):815-820.
[2] FERRANDIZ-PULIDO C,MARTIN-GOMEZ MT,REPISO T, et al. Cutaneous infections by dematiaceous opportunistic fungi:diagnosis and management in 11 solid organ transplant recipients[J]. Mycoses,2019,62(2):121-127.
[3] 刘泽虎,夏修蛟,钟燕,等. Microsphaeropsis arundinis引起暗色丝孢霉病一例[J].中华皮肤科杂志,2013,46(8):554-556.
[4] 冯雨苗,吴丽娟,王淼淼,等. Microsphaeropsis arundinis引起面部皮肤暗色丝孢霉病一例[J].中华皮肤科杂志,2018,51(5):382-384.
[5] PENDLE S,WEEKS K, PRIEST M,et al. Phaeohyphomycotic soft tissue infections caused by the coelomycetous fungus Microsphaeropsis arundinis[J]. J Clin Microbiol,2004,42(11):5315-5319.
[6] HALL M R,BRUMBLE L M,MAYES M A,et al. Cutaneous Microsphaeropsis arundinis infection initially interpreted as squamous cell carcinoma[J]. Int J Dermatol,2013,52(1):84-86.
[7] ASAHINA A,KOBAYASHI M,NAKANO K,et al. Deep cutaneous infection with Microsphaeropsis arundinis:report of two Japanese cases[J]. Acta Derm Venereol,2015,95(7):855-857.
[8] CRAWFORD S J,CHEN S C,HALLIDAY C,et al. Microsphaeropsis arundinis skin and soft tissue infection in renal transplant recipients:three case reports and a review of the literature[J]. Transpl Infect Dis,2015,17(6):915-920.
[9] NGUYEN Y,DODDS T,LOWE P. Cutaneous Microsphaeropsis arundinis infection in renal transplant recipients-A report of 2 cases and review of the literature[J]. JAAD Case Reports,2018,4(5):415-417.
[10] 姚璐,Microsphaeropsis arundinis引起播散性暗色丝孢霉病1例报道并文献复习[D].广西医科大学,2018:1-55.
[11] CHOI H,KIM CJ,KIM MS,et al. A case of subcutaneous and intranasal phaeohyphomycosis caused by Microsphaeropsis arundinis in an immunocompromised patient misdiagnosed with mucormycosis[J]. Ann Dermatol,2019,31(5):571-575.
[12] HANASHIRO F,YAMAGUCHI S,AWAZAWA R,et al. Cutaneous phaeohyphomycosis caused by Microsphaeropsis arundinis in a Japanese patient with cardiac sarcoidosis[J]. J Dermatol,2019,46(5):e170-e172.
[13] SANTOIEMMA P P,ASADBEIGI S N,GUITART J,et al. A case of Microsphaeropsis arundinis in a patient with acute leukemia[J]. Mycopathologia,2020,185(6):1091-1093.