The effects of microevolution on Trichosporon assahii infection

Abstract

Abstract: Objective To study the effects of microevolution on T. asahii infecting host and the immune response of the body. Methods Use the evolutional strain (TEVO) and original strain (TO) to infect the Balb/c mice, and comparing the differences of fungal relative load and MPO in the tissues、β-glucan in the serum and T cell differentiation in spleens. Results TEVO stains were almost spores, and TO stains were mycelia in morphology. The fungal relative load, MPO and β-glucan concentration of the TEVO group were significantly lower than those of the TO group. The CD4⁺T cells and CD8⁺T cells in the spleens of the TEVO group were more than that in the TO group. Conclusion The ability of the evolutional strain infecting host and the host defense to the evolutional strain in the early stage of infection were all lower than those of original strain, which may be closely related to the phenotype change of the evolutional strain.

Key words: microevolution, Trichosporium asahi, phenotype

CLC Number:

R379.9

PENG Zhuoying, LIAO Yong, BA Gen, YANG Xin, ZHANG Qianyu, YANG Rongya. The effects of microevolution on Trichosporon assahii infection[J]. Chinese Journal of Mycology, 2022, 17(3): 213-219.

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