Abstract: Objective The characteristics of the distribution of pathogen, drug susceptibility and risk factors of fungal infection in urolithiasis patients were analyzed to provide evidence for actively prevention and rational drug use. Methods From January 2017 to December 2019, 480 patients with urologic calculus and suspected infection diagnosed in the urology department of our hospital were selected. According to the results of urine culture, 59 patients with fungal infection were included in the observation group, 421 patients with non-fungal infection were included in the control group, SPSS 22.0 software was used for statistical analysis of the characteristics of the distribution of pathogenic fungi, drug susceptibility and risk factors of patients with fungal infection. Results ①Fungal distribution: among the 59 cases of fungal infection, the candida tropicalis infections was the most common, accounting for 20 cases (33.9%). ②Drug sensitivity characteristics: The resistance rates of fungi to amphotericin B, 5-fluorocytosine, voriconazole, fluconazole and itraconazole were 0, 1.7%, 16.9%, 22.0% and 23.7%, respectively. ③Risk factors: Multivariate Logistic regression analysis showed that diabetes, hypoalbuminemia and abnormal renal function were independent risk factors for fungal infection (P<0.05). Conclusions The most common pathogenic fungus in urolithiasis patients in our hospital was candida tropicalis. Doctors should take measures to prevent fungal infection according to the risk factors and use antibiotics rationally.

Key words: urolithiasis, fungus, infection, drug susceptibility, risk factor