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Chinese Journal of Mycology　2021, Vol. 16 　Issue (4): 234-242.

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Distribution characteristics of invasive yeast infections in China Hospital Invasive Fungal Surveillance Net(CHIF-NET) in 2012

DUAN Simeng1,2, XIAO Meng1,2, HUANG Jingjing1,2, WANG He3, ZHANG Ge1,2, ZHANG Jingjia1,2, KANG Wei1,2, WANG Tong1,2, XIAO Yuling4, NI Fang5, GAO Lanmei6, YE Liyan7, GUO Penghao8, WAN Zhe9, CHEN Zhongju10, YANG Qing11, LIN Jie12, HU Qingfeng13, LI Hongling14, YUE Na15, CUI LanYing16, LI Gang17, FAN Hui18, SU Danhong19, LIU Liwen20, TIAN Sufei21, ZHAO Shengyuan22, DU Xuefei23, ZHOU Hongwei24, XU Yingchun1,2   

  1. 1. Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China;
    2. Beijing Key Laboratory for Mechanisms Research and Precision Diagnosisof Invasive Fungal Diseases, Beijing 100730, China;
    3. Dana(Tianjin) Biotechnology Co., Ltd, Tianjin 300451, China;
    4. West China Hospital of Sichuan University, Chengdu 610041, China;
    5. Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China;
    6. Fujian Medical University Union Hospital, Fuzhou 350001, China;
    7. Medical School of Chinese PLA, Beijing 100036, China;
    8. The First Affiliated Hospital, SUN Yat-san University, Guangzhou 510080, China;
    9. Peking University First Hospital, Beijing 100034, China;
    10. Tongji Hospital, Tongji Medical College of HUST, Wuhan 4300030, China;
    11. The First Affiliated Hospital of the Zhejiang University School of Medicine, Hangzhou 310003, China;
    12. Sir Run Run Shaw Hospital, Hangzhou 310016, China;
    13. Zhejiang Province People's Hospital, Hangzhou 310014, China;
    14. Xiangya Hospital, Central South University, Changsha 410008, China;
    15. General Hospital of Tianjin Medical University, Tianjin 300052, China;
    16. The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China;
    17. General Hospital of Ningxia Medical University, Yinchuan 750001, China;
    18. Shandong Provincial Hospital, Jinan 250021, China;
    19. The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China;
    20. The People's Hospital of Liaoning Province, Shenyang 110000, China;
    21. The First Hospital of China Medical University, Shenyang 110001, China;
    22. Ruijin Hospital, Shanghai Jiaotong University of Medicine, Shanghai 200025, China;
    23. The Fouth Affiliated Hospital of Harbin Medical University, Harbin 150001, China;
    24. The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310052, China
  • Received:2020-05-09 Published:2021-08-31

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Abstract: Objective Incidence rate of invasive yeasts increased significantly in China. This study reported the datas of the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) in 2012. Methods A total of 1619 Candida strains were collected from 22 hospitals in China. The sensitivity of fluconazole and voriconazole were determined by matrix-assisted laser desorption/ionization time of flight mass spectrometry and ITS sequencing. The drug sensitivities of fluconazole and voriconazole were determined by kirby Bauer, K-B, recommended by the American institute of clinical laboratory standardization (CLSI). Results In this study, 626 strains from blood samples accounted for 38.67%.There were 993 strains from other parts (including ascitic fluid, pus, venous catheter, cerebrospinal fluid, bronchoalveolar lavage fluid, bile, pleural fluid, tissue, hydrarthrosis and gastric juice), accounting for 61.33%. Among them, 354 strains isolated from ascites accounted for 21.8%, 159 strains isolated from pus accounted for 9.8%, and fewer strains isolated from other sample types (<8%). Among 1619 strains of Candida isolated Other parts except blood, 491 strains were mainly Candida albicans, accounting for 49.45%,followed by 164 strains of Candida tropicalis, accounting for 16.52%, and the number of other species was small (<10%). Among the patients with invasive yeast detected, there were 1,006 male patients accounting for 62.1% and 612 female patients accounting for 37.8%. The age range was 0-94 years old, among which 498 patients ≥ 65 years accounted for 30.76%. In invasive candida infection, most Candida albicans were sensitive to fluconazole and voriconazole (R<1%), followed by Candida parapsilosis (R<6%) and Candida tropicalis (R<7%). In addition, different Candida species have different geographical distribution. Conclusion Studies howed that the distribution of invasive yeast infection in China was related to many factors including infection site, region and age. Therefore, continuous monitoring is needed.

Key words: invasive yeast, distribution characteristics, fluconazole, voriconazole

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