Distribution of Malassezia species on the face of patients with atopic dermatitis of head and neck

Abstract

Abstract: Objective To investigate the distribution of Malassezia in patients with head and neck atopic dermatitis(AD) and its relationship with severity. Methods From September to December, 2020, 45 AD patients and 50 healthy volunteers were recruited. Scale samples were taken from the lesion and non-lesion areas on the face both of patients and volunteers with sterile cotton swabs, and the number of copies of 7 species of Malassezia were detected by quantitative real-time PCR. The species distribution and number were analyzed by using cross-sectional analysis. Results For head and neck AD patients,the Malassezia restricta and Malassezia globosa in the facial lesions were 3.13 times (P<0.05) and 6.69 times (P<0.05) of the healthy volunteers, respectively. Both of them were correlated with the severity of AD (P<0.05). Conclusion Malassezia restricta and Malassezia globosa of lesion areas on the face were more in head and neck AD patients than that in healthy people, and their levels were correlated with the severity of the disease.

Key words: Malassezia, atopic dermatitis, quantitative real-time PCR, skin, colonization

CLC Number:

R379.9

LIN Jie, YANG Lianjuan, YANG Mingzhen. Distribution of Malassezia species on the face of patients with atopic dermatitis of head and neck[J]. Chinese Journal of Mycology, 2021, 16(3): 161-165.

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