Abstract: Objective To improve the understanding of fusariosis, especially disseminated fusariosis, in patients with hematopoietic stem cell transplantation, so as to achieve early diagnosis and timely treatment, and improve the prognosis. Methods To retrospectively analyze the diagnosis, treatment and prognosis of 4 cases of hematopoietic stem cell transplant patients with disseminated fusariosis treated in our hospital, from April 2015 to September 2020. Results All the 4 patients were confirmed cases that occurred before hematopoietic stem cell implantation or neutrophilic phase, and received amphotericin B liposome combined with voriconazole. Disseminated fusariosis was controlled in 3 patients, and one patient died after treatment. Conclusion Disseminated fusariosis after hematopoietic stem cell transplantation had poor prognosis and high mortality. Effective antifungal therapy and rapid immune reconstruction in early stage were effective means to improve the survival.

Key words: disseminated infection, Fusarium, hematopoietic stem cell transplantation