A retrospective analysis of the global cases caused by Exophiala dermatitidis

Abstract

Abstract: Objective To analyze the epidemiological trends and clinical characteristics of global cases caused by Exophiala dermatitidis, and to provide a scientific basis for improving the clinical diagnosis and treatment of E. dermatitidis infections. Methods Using the method of literature review and meta-analysis to analyze the nationality, gender, age, risk factors, onset organs, clinical manifestations, diagnosis, treatment and prognosis for epidemiological and clinical characteristics of E. dermatitidis worldwide. Results E. dermatitidis infections could occur in immunocompetent and immunocompromised hosts. The gender ratio of the patients was 1.10:1.00, The most common age of onset was ranging from 51~60 years old. The lung (27.90%, 17/61) was the most frequently-affected organ, but the most common sites are different between in different regions. Approximately half (47.54%) of the patients had various underlying diseases or risk factors. Diagnosis of E. dermatitidis infections mainly relied on culture and molecular identification. For systemic infections caused by E. dermatitidis, combination of itraconazole and terbinafine were recommended. Conclusion The incidence of E. dermatitidis infections has increased recently. The most commonly-affected organs in systemic infections are lungs, and the diagnosis mainly depends on culture. Strengthening the antifungal susceptibility monitoring and the investigation of epidemiology for E. dermatitidis are crucial to improve the diagnosis and treatment of E. dermatitidis infections.

Key words: Exophiala dermatitidis, epidemiology, clinical features, phaeohyphomycosis

CLC Number:

R519.8

ZHU Xinlin, HONG Nan, ZHANG Chao, CAI Liangqi, LI Xinhua, DENG Shuwen, PAN Weihua, CHEN Min, LIAO Wanqing. A retrospective analysis of the global cases caused by Exophiala dermatitidis[J]. Chinese Journal of Mycology, 2021, 16(1): 35-43.

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