Clinical analysis of 76 pediatric cases of cryptococcal meningitis

Abstract

Abstract: Objective To analyze the clinical features of cryptococcal meningitis in children. Methods Clinical date of 76 children with cryptococcal meningitis were analyzed. Results There were 47 males and 29 females, with an average age of (6.34±3.67) years. The main clinical manifestations were fever (100%), headache (78.95%) and vomiting (81.58%). The etiological test turned out that the positive rate of cerebrospinal fluid ink staining accounted for 60.53% (46 cases), the cryptococcal culture positive rate accounted for 27.63%(21 cases) at the first time. There were 74.19% patients cured after receiving the combined treatment of amphotericin B and 5-fluorocytosine, 62.96% patients cured after receiving the treatment of amphotericin B and fluconazole, but the difference was not statistically significant(P=0.75). Conclusions Crypotococcal meningitis in children was easely misdiagnosed, multiple and repeated lumbar punctures were beneficial to the diagnosis. amphotericin B combined with 5-fluorocytosine was the first choice for antifungal therapy.The key to improve the prognosis was early diagnosis and reduce intracranial pressuer effectively.

Key words: children, cryptococcal meningitis, clinical analysis

CLC Number:

R519.4

LIU Wenhui, CHEN Junhua. Clinical analysis of 76 pediatric cases of cryptococcal meningitis[J]. Chinese Journal of Mycology, 2021, 16(1): 24-28.

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