Abstract: Objective To analyze the prevalence, clinical characteristics and serological markers of pneumocystis jirovecii pneumonia (PJP) patients in this region, and to provide theoretical basis for early prevention and early diagnosis of PJP. Methods A retrospective study of 49 hospitalized patients with PJP from January 2016 to December 2019 in three general hospitals in jiangxi province was conducted. Information was collected regarding patient demographics, clinical manifestations, risk factors, laboratory analyses, radiological images, and treatment outcomes. Results The vast majority of PJP were HIV negative (89.8%) and were predominantly found in middle-aged males. HIV/AIDS, kidney disease (47.7%) and connective tissue disease (29.6%) were the main risk factors for PJP. The main clinical manifestations were dry cough (83.7%), white phlegm, and fever (79.6%), followed by dyspnea. The PJP patients had received glucocorticoid, immunosuppressant and/or chemotherapy in a low dose or for a short duration (<3 months). Biochemical investigations of Neu%, CRP, PO₂, LDH, and KL-6 showed that over 85% of cases exceeded the reference range of indicators. Conclusion HIV-negative patients infected with PJ were increasing, and renal disease and connective tissue disease might be main risk factors. LDH, BG and kl-6 might be used as important auxiliary examinations for PJP patients.

Key words: Pneumocystis jirovecii, pneumonia, HIV, KL-6