Abstract:

Objective To analyze the clinical characteristics of AIDS patients with invasive cryptococcus, and to provide reference for diagnosis and treatment. Methods The clinical data of inpatients diagnosed with AIDS complicated with invasive cryptococcosis in our hospital from January 2017 to December 2018 were retrospectively analyzed, and the data of clinical manifestations, laboratory examination, clinical treatment plan and outcome were systematically analyzed. Results A total of 30 patients were included. The clinical manifestations were fever, weight loss and fatigue. The CD4 T lymphocyte count was lower than 100cells/ L, and the white blood cells were significantly decreased by routine blood examination. The strain was sensitive to 5-fluorocytosine, amphotericin B, fluconazole injection and voriconazole. Lumbar puncture in patients with invasive cryptococcal meningitis indicated increased intracranial pressure, and cerebrospinal fluid biochemistry indicated low glucose, low chloride and high protein. Clinically, four treatment regimens were mainly used, among which amphotericin B combined with fluconazole was more common, and the average length of stay was more than 40d. Conclusion AIDS patients with invasive cryptococcosis infection of blood flow, patients with infection of blood flow with cryptococcus isolates have a good prognosis, patients with infection of blood flow with cryptococcus isolates have a high fatality rate, and high intracranial pressure is one of the prognostic factors. Clinical timely HAART is the key to good treatment and prognosis.

Key words: AIDS, invasive cryptococcosis, bloodstream infection, clinical characteristics