Abstract:

Objective To investigate the distribution characteristics and drug resistance of Candida isolates from vaginal secretion specimens in women from a region of Guizhou Province, and to provide a reference for clinical treatment. Methods A total of 2055 female cases in a region of Guizhou Province from January to December 2018 were collected. Culture and drug sensitivity test of Candida vaginal isolates from secretion samples, and statistical analysis of the results were performed. Results A total of 543 Candida strains were isolated and identified, with the highest isolation rate of Candida albicans, accounting for 40.5%,Candida glabrata and Candida Parapsilosisis accounting for 35.0% and 19.7%, respectively. Infected patients were most common in the age group of 26~30 (39.2%), followed by 21~25 age group (25.4%) and 31~35 age group (19.2%); 90.4% of infected patients were 21 to 40 years old. The resistance of different Candida antifungal drugs was quite different, and no resistant Candida isolate to micafungin, nystatin and caspofungin was found. Non-Candida albicans isolates were significantly more resistant to itraconazole, fluconazole and ketoconazole(P<0.01), there was no significant difference in the rates of 5-fluorocytosine resistance(P>0.05). Conclusion Candida albicans is more common isolate among women in this area of Guizhou Province, and the drug resistance of different Candida species was not similar. Clinical reasonable treatment plan should be developed according to different pathogenic resistant characteristics.

Key words: Candida vagina, infection, drug resistance, antifungal drugs