Clinical analysis for 67 AIDS patients with cryptococcal meningitis

Abstract

Abstract:

Objective To investigate the clinical characteristics of AIDS patients with cryptococcal meningitis. Methods We collected and analyzed the clinical data including clinical presentation, laboratory examination, therapeutic regimen and outcome on AIDS patients with cryptococcal meningitis from Beijing You'an Hospital during 1 January 2010 and 31 December 2016. Results There were 67 AIDS patients with cryptococcal meningitis in this study, including 60 male and 7 female. The most common clinical symptoms were headache (74.6%), fever (47.8%), nausea and vomiting (40.3%). Increased intracranial pressure was found in 78.9% patients, the mean pressure was 216.6 (±100.3 mm H₂O), and the baseline CD4⁺ T cell was 53.7 (±79.9)/mm3. The mortality rate was 29.9% (20/67). Conclusion Cryptococcal meningitis with high mortality rate was severe complication of AIDS. Early diagnosis and standard treatment was key to reduce injury of Cryptococcus on brain, and to save lives.

Key words: AIDS, cryptococcal meningitis, clinical characteristic

CLC Number:

R519.4

WANG Li-lin, LI Ai-xin, YANG Xue, Wang Wen, Wu Hao. Clinical analysis for 67 AIDS patients with cryptococcal meningitis[J]. Chinese Journal of Mycology, 2019, 14(6): 342-345.

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