Isolates distribution and drug sensitivity test of invasive yeast-like fungi infection in Hebei

Chinese Journal of Mycology　2019, Vol. 14 　Issue (4): 222-227.

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Isolates distribution and drug sensitivity test of invasive yeast-like fungi infection in Hebei

LI Fang¹, LI zhi-rong², ZHAO Ying³, ZHAO Jian-hong², ZHANG Yan-hai⁴, DONG Ai-ying⁵, LIU Jin-lu⁶, GUO Yan-yan⁷, SUN Yan⁸, ZHAO Wen-shen⁹, XIE Shou-jun¹⁰, WEI Hong-lian¹¹, ZHANG Jin-yan¹², REN Hong-tao¹³, WANG Jian-sheng¹⁴, WU Xiang-kun⁴, GUANG Xiao¹⁵, LI Dong-qing¹⁶, DU Hong-li¹⁷, GUO Ying-hui¹⁸, XU Ying-chun³, XIAO Meng³, YANG Wen-Hang³, XU Xiao-lin⁴

1. Herbei Yanda hopstial, Langfang 065201;Chao yang Hospital Affilliated to the Capital University of Medical Science, Beijing 100020, China;
2. The Second Hospital of Hebei Medical University, Clinical Laboratory Center of Hebei Province, Shijiazhuang 050000, China;
3. Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences;Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing 100730, China;
4. Herbei Yanda hopstial, Langfang 065201;
5. North China University of Science and Technology Affiliated Hospital, Tangshan 063000;
6. The First Affiliated Hospital of Hebei North University School of Clinical Medicine, Zhangjiakou 075000;
7. Department of Endocrinology, Tangshan Gongren Hospital, Tangshan 063000;
8. Cangzhou Central Hospital, Cangzhou 061001;
9. The Central Hospital of Handan, Handan 056001;
1
0. Affiliated Hospital of Chengde Medical College, Chengde 067000;
1
1. The Second Hospital of Hebei Medical University, Shijiazhuang 050000;
1
2. Fourth Hospital Affiliated to Hebei Medical University, Shijiazhuang 050019;
1
3. People's Hospital of Xingtai City, Xingtai 054001;
1
4. Hebei Provincial People's Hospital, Shijiazhuang 050057;
1
5. The First People's Hospital of Wu'an City, Wuan 056300;
1
6. Handan First People's Hospital, Handan 056002;
1
7. People's Hospital of Hengshui City, Hengshui 053000;
1
8. Hebei Children's Hospital, Shijiazhuang 050030

Received:2019-05-12 Online:2019-08-28 Published:2019-08-28

Abstract

Abstract:

Objective To investigate the composition, distribution and in vitro drug sensitivity of invasive yeast-like fungi infections isolates in 16 tertiary teaching hospitals in Hebei, and to provide a reference for the rational use of antifungal drugs. Methods The isolated strains of invasive yeast-like fungi infection patients in Hebei were collected, and the composition of the strains was analyzed, Sensititre YeastOne color sensitive plate was used to test the susceptibility of 9 antifungal agents. Results A total of 260 invasive yeast strains were detected, of which C. albicans was the most important pathogen (42.31%), and non-C.albicans (57.69%), including C.tropicalis (19.23%), C.parapsilosis complex(18.08%)and C.glabrata(9.23%).The resistance rates of C. albicans to fluconazole, voriconazole and itraconazole were 2.8%, 1.9% and 0.9%, respectively. The resistance rates of C.tropicalis to fluconazole and voriconazole were 12.8%. The resistance rates of C.parapsilosis complex to fluconazole and voriconazole were 14.9% and 10.6%, respectively. The resistance rate of C.albicans, C.tropicalis and C.parapsilosis complex to echinococcins was almost 0%. Conclusion C.albicans was the most common pathogen ofinvasive yeast-like fungi infection, but non-C.albicans infection had exceeded 50%. C. albicans was still highly susceptible to antifungal drugs, but the susceptibility rates of azoles were different among different Candida species. Echinomycins had high activity against C. albicans, C. tropicalis and C. parapsilosis.

Key words: invasive yeast fungi, distribution of strains, drug sensitivity test

CLC Number:

R519

LI Fang, LI zhi-rong, ZHAO Ying, ZHAO Jian-hong, ZHANG Yan-hai, DONG Ai-ying, LIU Jin-lu, GUO Yan-yan, SUN Yan, ZHAO Wen-shen, XIE Shou-jun, WEI Hong-lian, ZHANG Jin-yan, REN Hong-tao, WANG Jian-sheng, WU Xiang-kun, GUANG Xiao, LI Dong-qing, DU Hong-li, GUO Ying-hui, XU Ying-chun, XIAO Meng, YANG Wen-Hang, XU Xiao-lin. Isolates distribution and drug sensitivity test of invasive yeast-like fungi infection in Hebei[J]. Chinese Journal of Mycology, 2019, 14(4): 222-227.

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Isolates distribution and drug sensitivity test of invasive yeast-like fungi infection in Hebei

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