Clinical analysis of 12 cases with cutaneous mucormycosis caused by Rhizopus arrhizus

Abstract

Abstract:

Objective To analyze clinical features of cutaneous mucormycosis caused by Rhizopus arrhizus since 1991 in China, and to further explore the typical clinical manifestation, predisposing factors, treatment strategies and prognosis. Methods Cases infected with rhizopus arrhizus reported in various data bases of China were searched thoroughly, clear diagnostic evidence should be described. Results Twelve cases were included in this paper. There were 10 males and 2 females separately, the average age of those patients was 46.83 years old. Uncontrolled diabetes mellitus was the most common risk factor and traumatic history could always be found in most cases. Aggressive erosion and ulcer were the most common clinical manifestations, and black eschar could be served as a clue to diagnosis. Combination amphotericin B with topical debridement was the most common treatment. Of all the patients, 3 of them resulted in death, 9 patients received favorable results of antifungal agents, but 2 cases underwent amputation surgery pitifully. Conclusions Rhizopus arrhizus was one of the most common pathogens causing mucormycosis, which might lead to death and deformity. Early diagnose and individual treatment are of great importance in saving lives and improving life qualities.

Key words: mucormycosis, cutaneous, Rhizopus arrhizus, clinical analysis

CLC Number:

R519
R756.6

LIU Jia, LIANG Guan-zhao, YANG Jia, GE Li-yu, DONG Jia-cheng, LIU Wei-da. Clinical analysis of 12 cases with cutaneous mucormycosis caused by Rhizopus arrhizus[J]. Chinese Journal of Mycology, 2019, 14(1): 20-23.

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