The current therapeutics and research progress of topical antifungal agents

Abstract

Abstract:

Onychomycosis is widespread with a low initial treatment rate, high recurrence rate and high re-infection rate. The commonly used methods include topical and oral medications. Due to the side effects and drug-drug interactions of oral antifungal agents, it is mainly focused on the development of topical antifungal antimycotics in recent years. The mechanism, efficiency related to experiments in vitro or vivo and research progress of topical antifungal formulations including traditional drugs (amorolfine and ciclopirox), novel drugs (efinaconazole and tavaborole) and drugs under development (terbinafine hydrochloride, luliconazole, ME1111 and tazarotene) are reviewed in this paper.

Key words: onychomycosis, topical antifungal agents, mechanism, research progress

CLC Number:

R756.4

SONG Na-na, ZHOU Xiao-wei, LI Xiao-fang, LIU Wei-da. The current therapeutics and research progress of topical antifungal agents[J]. Chinese Journal of Mycology, 2018, 13(3): 184-187.

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