Analysis on pathogenic distribution and sensitivity of nosocomical candidemia

Abstract

Abstract:

Objective To investigate the pathogen distribution and drug resistance of Candida bloodstream infection. Methods The data of Candida isolated from blood culture were retrospectively analyzed in the Wuxi No.2 People's Hospital from 2013 to 2016. Results Fifty-six pathogenic Candida strains were isolated, which included Candida albicans (57%,32/56), Candida parapsilosis (20%,11/56) and Candida glabrata (15.8%,9/56). The patients mainly came from the ICU (23.2%,13/56) and the department of Nephrology (17.9%, 10/56). The difference of sensitivity rates between Candida albicans and non-albicans candida was notable, which were 93.8% and 62.5%. The sensitivity rates of 56 Candida strains to amphotericin B and flucytosine were 100%. The sensitivity rates of Candida glabrata and Candida parapsilosis to fluconazole were 55.6% and 72.7%. All the Candida krusi strains were resistance to fluconazole. Conclusions The main pathogenic Candida isolated from bloodstream infection was Candida albicans. The sensitivity tests showed that non-albicans candida species had relatively strong endurance to fluconazole. Therefore, drug resistance should be considered in the selection of antifungal drugs.

Key words: Candida, blood culture, drug sensitivity analysis

CLC Number:

R519.3

HUA Hai-kang, LAI Mei-ling, HU Ren-jing, ZHANG Hai-ping, ZHOU Cheng-long, ZHANG Xiao-li, GE Xiao-li. Analysis on pathogenic distribution and sensitivity of nosocomical candidemia[J]. Chinese Journal of Mycology, 2018, 13(3): 173-176.

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