Clinical features and etiological analysis of fungal keratitis in diabetic patients

Abstract

Abstract:

Objective To investigate the clinical features and etiology of diabetic fungal keratitis in diabetic patients,to find out the main risk factors for the prognosis. Methods A retrospective study was used.From February 2013 to May 2016,120 patients in our hospital diagnosed as fungal keratitis with complete clinical data were enrolled,including 60 cases of diabetic fungal keratitis (diabetic group) and 60 cases of non-diabetic fungal keratitis (non-diabetes group).All the demographic characteristics,clinical symptoms,etiological examination results were recorded,and the patient's prognosis and risk factors were also recorded. Results There were no significant differences in gender,BMI,duration of disease (P>0.05) between two groups.The average history of diabetes in the diabetic group was 8.14±2.11 years.The age and corneal infection severity scores compared between the diabetic group and the non diabetes group were significantly different (P<0.05).In the diabetic group,there were 10 cases of Fusarium sp (16.7%),40 cases of Aspergillus sp (66.7%),10 cases of Candida (16.7%).In the non diabetes group,there were 25 cases of Fusarium sp (41.7%),30 cases of Aspergillus sp (50%),5 cases of Candida (8.3%).The distribution of fungal infections in two groups showed statistical significantly difference (P<0.05).The total effective cure rate of diabetic group and non-diabetic group were 86.7% and 98.3%,respectively.Multi-variable Logistic regression analysis showed that the main risks for prognosis were infiltration lesions,hypopyon and Aspergillus in the diabetic fungal keratitis patients (P<0.05). Conclusion Compared with those in non-diabetic group,fungal keratitis patients in diabetic group was more older.Aspergillus was the main pathogen.The infiltration lesions,hypopyon and Aspergillus were the main prognosis risk factors in the diabetes fungal keratitis patients.

Key words: fungal keratitis, clinical features, etiology, prognosis, risk factors

CLC Number:

R772.21
R519

Wang Rui. Clinical features and etiological analysis of fungal keratitis in diabetic patients[J]. Chinese Journal of Mycology, 2017, 12(4): 221-224.

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