Abstract:

Objective To evaluate the efficacy and safety of 1% luliconazole cream in the treatment of tinea corporis and tinea cruris.Methods A single-center,single-blind,randomized,positive drug (1% terbinafine hydrochloride cream) controlled trial was conducted.Both 1% luliconazole cream and 1% terbinafine hydrochloride cream were applied once daily for 2 weeks to the rashes.Patients were evaluated at 0 (baseline),1,2 and 4 weeks.Results Thirty cases in the trial group and 28 cases in the control group were evaluated.The effective rate at 1 week was 43.33% in the trial group and 28.57% in the control group (P>0.05);96.67% versus 85.71% at 2 weeks and 96.67% versus 100.00% at 4 weeks respectively (P>0.05).Mycological cure rates at 1 week both were 50% in the trial group and control group;96.67% versus 85.71% at 2 weeks and 96.67% versus 100.00% at 4 weeks respectively (P>0.05).Treatment-related adverse events were not seen in this study.Conclusion This study suggests that 1% luliconazole cream was effective and safe in the treatment of tinea corporis and tinea cruris.

Key words: luliconazole, terbinafine, tinea corporis, tinea cruris