Abstract:

Objective To investigate the curative efficiency and safety of luliconazole 1% cream in treating candidal balanoposthitis.Methods A total of 70 outpatients from department of Dermatology & STD were randomly divided into two groups.Among them,38 were given luliconazole 1% cream once a day (study group) while the others were given ketoconazole cream once a day (control group).The effect was evaluated based on scores of relief for symptoms,skin signs,and mycology inspection,while the safety was evaluated according to the side effects.Results The mycological clearance rate of 1% luliconazole cream was significantly higher than that of 2% ketoconazole cream one week after treatment (P<0.05),but there was no significant difference of clinical efficacy and mycological clearance rate between the two groups two weeks after treatment (P>0.05).No significant difference was observed between the two groups in evaluation scores of clinical effect,symptom and skin sign aspects.Conclusion The curative effect and safety for 1% luliconazole cream were comparable to those of 2% ketoconazole cream in treating candidal balanoposthitis.It is worth popularizing and applying clinically.

Key words: luliconazole, candidal balanoposthitis, curative effect