Abstract:

Objective To study antifungal activity of lavender essential oil in vitro and the effect on biofilm of Candida albicans.Methods Disk diffusion and microdilution were used to determine the susceptibility and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Candida albicans to lavender essential oil.XTT reduction assay was performed to determine the SMIC50 of lavender essential oil to C.albicans biofilms.The effect of lavender essential oil on morphogenesis of C.albicans biofilms was observed by inverted microscopy.Results The standard strain of Candida albicans was highly sensitive to lavender essential oil.MIC of Lavender essential oil to Candida albicans was 12.5 μL/mL,MBC was 25 μL/mL.SMIC50 of lavender essential oil to C.albicans biofilms was 100 μL/mL.Lavender essential oil could inhibit the filamentous growth.Conclusion Lvender essential oil had antifungal activity against Candida albicans in vitro.

Key words: lavender essential oil, Candida albicans, MIC, MBC, biofilm