Re-evaluation of the clinical value of (1,3)-β-D-glucan detection in the invasive fungal infections

Abstract

Abstract:

Objective To investigate the diagnostic value of (1,3)-β-D-glucan test (G test) in invasive fungal disease.Methods Retrospectively study the inpatient results of clinical G test from Jan.2014 to Jun.2014 at The First Affiliated Hospital of Chongqing Medical University and analyse the sensitivity,specificity,coincidence rate,positive predictive value,negative predictive value and Youden index of G test in fungal infection.Results The G test value of fungal infection group was 228.4±250.1 pg/mL,and the G test value of non-fungal infection group was 32.6±13.6 pg/mL.There were significant differences between the two groups (P<0.001).The sensitivity,specificity,coincidence rate,positive predictive value,negative predictive value and Youden index of G test in fungal infection were 83%,92%,88%,89%,87%,0.75,respectively.Conclusion G test is one of important early laboratory indexes in fungal infection,and the rational use of G test can effectively improve the diagnostic ability of fungal infection,especially for the negative exlusion.

Key words: (1,3)-β-D-glucan, G test, invasive fungal disease (IFD)

CLC Number:

R519

XIA Ji-rong, NIU Si-qiang, Cao Ju. Re-evaluation of the clinical value of (1,3)-β-D-glucan detection in the invasive fungal infections[J]. Chinese Journal of Mycology, 2016, 11(5): 269-271,274.

References

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