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Chinese Journal of Mycology 2016, Vol. 11  Issue (5): 261-264.

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Retrospective analysis of the clinical and laboratory features of 9 disseminated Talaromyces marneffei cases in non-HIV patients

WANG Peng1, ZHAI Li-hui2, FAN Hong-wei3, LIU Zheng-yin3, WANG Yao1, ZHAO Ying1, XIAO Meng1, ZENG Xue-jun4, SHI Ju-hong5, LIU Hong-rui6, FENG Rui-e6, XIE Xiu-li1, XU Ying-chun1   

  1. 1. Peking Union Medical College Hospital, PUMCH, 100730 Department of Clinical Microbiology Laboratory;
    2. Department of Clinical Laboratory, First Hospital Affiliated to the Chinese PLA General Hospital. Beijing 100048, China;
    3. Peking Union Medical College Hospital, PUMCH, 100730 Department of Infectious Diseases;
    4. Peking Union Medical College Hospital, PUMCH, 100730 Department of Internal Medicine;
    5. Peking Union Medical College Hospital, PUMCH, 100730 Department of Respiration;
    6. Peking Union Medical College Hospital, PUMCH, 100730 Department of Pathology
  • Received:2016-03-09 Online:2016-10-28 Published:2016-10-28

Abstract:

Objective This study aimed to enhance diagnoses of the clinical and laboratory features of Talaromyces marneffei (PM) in non-HIV patients.Methods We retrospectively analyzed the medical records and clinical characteristics of 9 patients diagnosed with (PM) from January 1,2008 to December 31,2015 in tertiary Hospital.Results There were 3 cases with underlying diseases and 6 cases without underlying diseases.Six patients had received immunosuppressant therapy before onset.Four patients occurred the bone damage and 2 cases had skin rash,swollen lymph nodes in 7 cases,weight loss in 5 cases,anaemia in 7 cases.Six cases accept anti-TB or NTM treatment.Six cases were cured or improved.Conclusion Patients with non-HIV/AIDS infectious PSM having certain common characteristics but with no specificity made early diagnosis difficult.It especially need to be differentiated from diseases such as tuberculosis.Early antifungal therapy is closely related to the correct prognosis of the patients.

Key words: Penicillium marneffei, non-HIV/AIDS patients, disseminated fungal infection, Talaromyces marneffei

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