Abstract:

Objective To investigate the efficacy and safety of different course of domestic luliconazole 1% cream in the treatment of candidal balanoposthitis.Methods Ninty patients were divided randomly and equally into 3 groups:A group applying luliconazole 1% cream once daily for 1 week;B group applying luliconazole 1% cream once daily for 2 weeks;C group applying ketoconazole 2% cream twice daily for 2 weeks.Efficacy,rates of mycological clearance and adverse reactions were assessed on week 1,2,4 after treatment.Result A total of 90 patients were enrolled and 86 patients were evaluated for efficacy.The clinical response rates in the three group were 69.0%,64.3% and 65.5% respectively(P>0.05),the rates of mycological clearance were 82.8%,85.7% and 86.2% respectively on week 1 after initiation of treatment(P>0.05).The clinical response rates in the three group were 72.4%,78.6% and 75.9% respectively;the rates of mycological clearance were 82.8%,85.7% and 86.2% respectively on week 2 after initiation of treatment(P>0.05).The clinical response rates in the three group were 75.9%,85.7% and 82.8% respectively;the rates of mycological clearance were 86.2%,85.7% and 89.7% respectively on week 4 after initiation of treatment(P>0.05).There were not significant differences in the efficacy and the rates of mycological clearance between three groups on week 1,2,4 after treatment.The incidence of adverse events was very low.All of the adverse events were mild local adverse events.Conclusion Domestic luliconazole 1% cream can be used effectively and safely in the treatment of candidal balanoposthitis,with the efficacy of 1-week regimen equivalent to that of 2-week regimen.

Key words: luliconazole, ketoconazole, candidal balanoposthitis