Express of Dectin-1 and related cytokines in skin with eumycetic mycetoma

Abstract

Abstract:

Objective To observe the expression of dectin-1 in the skin with eumycetic mycetoma,and to analyze the role of the pattern recognition receptors dectin-1 when the skin infected with eumycetic mycetoma.Methods There were three experiment al groups,group A included 8 cases of chromoblastomycosis,and group B contained 10 cases of mycetoma.The infection group included group A and B.The normal group contained 18 normal skin tissue.The expression of Dectin-1,IL-4,IL-10,IFN-γ and TNF-α were tested by immunohistochemical method in the paraffin embedded tissues.Results Compared with normal group,the integral optical density values of Dectin-1,IL-4,IFN-γ,TNF-α,IL-10 of the infected group were increased(P<0.05).The integral optical density values of Dectin-1 and IL-4,IFN-γ,TNF-α had no difference between group A and B.Conclusion Increased expression of Dectin-1 of the skin with eumycetic mycetoma,suggested that Dectin-1 might have a certain role on the skin with fungal infection.

Key words: Dectin-1, eumycetic mycetoma, IL-4, IL-10, IFN-γ, TNF-α

CLC Number:

R756.6

WU Fang-pei, HU Xiao-ping, YU Bo, CHEN Chao-feng, LIU Xiao-yun, HUANG Guo-xin. Express of Dectin-1 and related cytokines in skin with eumycetic mycetoma[J]. Chinese Journal of Mycology, 2016, 11(4): 201-204.

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