Abstract:

Objective To compare the efficacy and safety of 1% luliconazole cream and 1% terbinafine hydrochloride cream in the treatment of tinea pedis.Methods A single-center,single-blind,randomized controlled trial was conducted.1% luliconazole cream was applied in the trial group once daily for 2 weeks and 1% terbinafine hydrochloride cream in control group was applied twice daily for 2 weeks.Patients were evaluated at 0(baseline),2,4 weeks.Results Thirty cases in the trial group and 30 cases in control group were evaluated.The clinical effective rate at 2 weeks was 63.33% in the trial group and 76.67% in control group;and 93.33% versus 90.00% at 4 weeks respectively.Mycological cure rates at 2 weeks and 4 weeks were 46.67% and 86.67% in the trial group,and in control group they were 53.33% and 80.00% respectively.The total effective rate at week 2 was 43.33% in the trial group and 60.00% in control group;and 86.67% versus 80.00% at 4 weeks,respectively.Treatment-related adverse events consisted of local irritation,occurred in 3.33% of patients both in the trial group and control group.The efficacy and safety of 1% luliconazole cream in the treatment of tinea pedis are similar to that of 1% terbinafine hydrochloride cream(P>0.05).Conclusion This study suggests that 1% luliconazole cream was effective and safe in the treatment of tinea pedis.

Key words: luliconazole, terbinafine, tinea pedis