The value of the galactomannan antigen assay in diagnosis Penicilliosis marneffei

Abstract

Abstract:

Objective To evaluate the value of the galactomannan antigen assay in diagnosis Penicilliosis marneffei(PSM).Methods The serum samples were collected from 37 PSM patients,17 other fungal infection patients and 30 healthy volunteers.Platelia Aspergillus enzyme immunoassay kit was used.Results The sensitivities of total PSM patients,PSM patients with or without HIV infection were 78.38%,76.47%,75.00%,while their specificities were 82.98%,97.87%,84.78%,respectively.In 4 follow-up PSM patients,the GM decreased after anti-fungi treatment for 1 week as the clinical presentation improved.Conclusion This study showed that the GM test was significantly elevated for HIV patients with penicilliosis.The use of the GM antigen assay may facilitate earlier diagnosis of Penicillium marneffei infection for HIV-infected patients in areas of endemicity.

Key words: Penicilliosis marneffei, galactomannan, diagnosis

CLC Number:

R446.5

YAN Ru-fan, LI Xin-lei, ZHENG Dong-yan, LIN Bing, LIANG Hao, CAO Cun-wei. The value of the galactomannan antigen assay in diagnosis Penicilliosis marneffei[J]. Chinese Journal of Mycology, 2016, 11(1): 16-19.

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