Innate immune mechanisms for recognition Candida albicans

Abstract

Abstract:

Candida species are major causes of infections affecting either body surfaces or the deep tissues.Recognition of Candida spp by immune cells is mediated by dedicated pattern recognition receptors (PRRs), expressed on innate immune cells.PRRs recognize Candida-specific pathogenassociated molecular patterns (PAMPs).Binding of fungal PAMPs to PRRs triggers the activation of innate effector cells.Host-Candidainteraction can result either in rapid elimination of the pathogen or the persistence of the pathogen in immunocompromised patients, leading to either chronic mucocutanous candidiasis or invasive candidiasis.Several PRRS, such as Dectin-1, also play important roles in adaptive immunity defense against fungi by preferentially inducing Th17 cell differentiation.Here, we discuss the molecular basis of receptor-mediated recognition and uptake of Candida and we describe the relative role of these receptors in initiating inflammation.

Key words: Candida albicans, pattern recognition receptors, pathogen associated molecular patterns, Innate immunity

CLC Number:

R379.4

YANG Long, JIA Xin-ming, JIANG Yuan-ying. Innate immune mechanisms for recognition Candida albicans[J]. Chinese Journal of Mycology, 2015, 10(4): 236-240.

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