Progress on the study of innate immune response to Cryptococcus neoformans

Abstract

Abstract:

Innate immunity is the first line of the host immune system fighting against invading pathogens.Pattern recognition receptors (PRRs) are responsible for recognition of pathogens and their components.And the nucleotide oligomerization domain (Nod)-like receptors (NLRs) are intracellular PRRs.In recognition of pathogens infection, some NLRs including NLRP3, NLRP1 and NLRC4 form large protein complexes called inflammasomes, which mediate maturation of pro-inflammatory cytokines IL-1β and IL-18.Inflammasomes are important in anti-fungal immunity.Cryptococcus neoformans is an opportunistic fungal pathogen, mainly infecting immunocompromised patients and causing high mortality.Here we review recent progresses on host innate immune response against Cryptococcus neoformans.

Key words: innate immunity, inflammation, inflammasome, fungi, Cryptococcus neoformans

CLC Number:

R519.4

MENG Guang-xun, GUO Cai-qin, CHEN Ming-kuan. Progress on the study of innate immune response to Cryptococcus neoformans[J]. Chinese Journal of Mycology, 2015, 10(4): 193-196.

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