Dendritic cells in anti-fungal immunity

Abstract

Abstract: The number of life-threatening fungal infections has skyrocketed recently as a result of the abused of antibiotics,chemotherapy drugs and immunosuppressive drugs,as well as the increased immunocompromised patients.Dendritic cells(DCs)are the most powerful antigen-presenting cells.As the bridge between the innate and adaptive immune system,DCs play a central role in recognizing a variety of pathogens and presenting antigens.Many investigations demonstrate that DCs can effectively recognize fungal pathogens through several receptors on the cellular surface and promote the immune responses against invasive fungi.Here,we describe the characteristics of the various DCs subsets,the way of DC recognizing fungi,and their functions in immunity against fungal pathogens.

Key words: dendritic cells, fungal infection, immune response

CLC Number:

R519

WANG Rui-li, LIAO Yong, AO Jun-hong. Dendritic cells in anti-fungal immunity[J]. Chinese Journal of Mycology, 2015, 10(1): 39-43,21.

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