Trends of fungal spectrum and drug resistance changes in Intensive Care Unit

Abstract

Abstract: Objective To investigate the trends of fungal spectrum and drug resistance changes in Intensive Care Unit in six years.Methods One-thousand four hundred and thirty five stains of first-time isolated fungi were isolated during 2007-2012 in ChangZheng Hospital Intensive Care Unit. Cox-Stuart test was used to analysis trends in distribution of fungi and drug resistance changes in this retrospective study.Results During 2007-2012, the number of fungi inspected increased from 159 to 396 strains per year, among which the ratio of Candida albican,parapsilosis,aspergillus ranging 34.6%-50.3%,6.3%-9.6%,1.3%-3.2% with a trend of increase,P=0.02;Candida tropicalis,glabrata,and krusei ranging 13.6%-17.3%,9.4%-22.6%,1.4%-5.2%,P=0.18;The average drug resistant of Candida albican to itraconazole and fluconazole showed a trend of decrease P=0.02;The average drug resistant of Candida tropicalis to itraconazole and fluconazole showed a decreased trend as well,P=0.02 whereas the average drug resistant of Candida glabrata to itraconazoleshowed an increased trend,P=0.02.Conclusion The most common isolated strains of fungi in ICU were Candida albican,followed by Candida tropicalis and Candida glabrata.Candida albican,Candida parapsilosis and Aspergillus had increase ratio of distribution.There are decrease trends in the drug resistance of Candida albican and Candida tropicalis to fluconazole and itraconazole whereas Candida glabrata showed a increase trend to itraconazole.

Key words: Intensive Care Unit, fungal spectrum, drug resistance, trend

CLC Number:

ZHANG Wei, LIN Zhao-fen, ZHAO Jin, XU Shi-qiong, SHAN Hong-wei. Trends of fungal spectrum and drug resistance changes in Intensive Care Unit[J]. Chinese Journal of Mycology, 2014, 9(1): 24-27,33.

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