Penicilliosis marneffei with non-HIV-infected：two cases report and literature review

Abstract

Abstract: Objective To describe the clinical feature of penicilliosis marneffei and heighten the ratio of diagnosis and treatment.Methods Two cases of disseminated penicilliosis marneffei in immunocompetent hosts from this hospital were presented.Result Case 1: 37-year old, male, was admitted because of recurrent episodes of coughing and fever for one month and developed pain in both shoulders and dizziness. An enlarged left supraclavicular and inguinal lymph node were palpated. Cranial MRI showed intracalvarium and retropharyngeal abscess. Disseminated penicilliosis marneffei with secondary seizure was diagnosed by transbrochial lung biopsy (TBLB)and pus fungal culture. The patient received a treatment with amphotericin B liposome and recovered. Case 2: 32-year old, male, was admitted due to a productive cough for 5 months, subcutaneous mass with fever for 3 months. During the treatment with amphotericin B liposome intravenously patient developed septic shock and DIC.Conclusion As the first time in China, penicilliosis marneffei is reported to disseminate to central nervous system. TBLB and pus culture are useful for the the diagnosis. Amphotericin B liposome is effective for the recurrent disseminated Penicillium marneffei and early diagnosis is the key for the outcome of the patients with this treatment.

Key words: Penicilliosis marneffei, immunocompetent patient, disseminated

CLC Number:

R519.9

YE Feng, LUO Qun, ZHOU Ying, XIE Jia-xing, GU Ying-ying, SU Dan-hong, CHEN Rong-chang. Penicilliosis marneffei with non-HIV-infected：two cases report and literature review[J]. Chinese Journal of Mycology, 2013, 8(6): 342-347,377.

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