Advances in the MAPK signaling pathway of Candida albicans

Abstract

Abstract: Candida albicans is the most common opportunistic pathogen in humans. Mitogen-activated protein kinase (MAPK) chain is one of the most important ways of eukaryotic signal network and it plays a key role in regulating gene expression in the cytoplasm functions. There are mainly four MAPK signaling pathways in Candida albicans: Mkc1, Cek1, Cek2 and HOG. The HOG pathway plays an important role in MAPK signaling pathway of Candida albicans. The understanding about the role of MAPK signaling pathway in Candida albicans and related regulatory mechanism will provide help to find new drug targets and the treatment of candidiasis.

Key words: Candida albicans, MAPK signaling pathway, HOG pathway

CLC Number:

R379.4

WANG De, HUANG Xin, ZHAO Li-lan, ZHAO Jing-jun. Advances in the MAPK signaling pathway of Candida albicans[J]. Chinese Journal of Mycology, 2013, 8(4): 252-256.

References

[1] Monge RA, Roman E, Nombela C, et al. The MAP kinase signal transduction network in Candida albicans[J]. Microbiology,2006,152(Pt 4):905-912.
[2] Chauhan N, Calderone R. Two-component signal transduction proteins as potential drug targets in medically important fungi[J]. Infect Immun,2008,76(11):4795-4803.
[3] Cheetham J, Maccallum DM, Doris KS, et al. MAPKKK-independent regulation of the Hog1 stress-activated protein kinase in Candida albicans[J]. J Biol Chem,2011,286(49):42002-42016.
[4] Hohmann S. Osmotic stress signaling and osmoadaptation in yeasts[J]. Microbiol Mol Biol Rev,2002,66(2):300-372.
[5] Kayingo G, Wong B. The MAP kinase Hog1p differentially regulates stress-induced production and accumulation of glycerol and D-arabitol in Candida albicans[J]. Microbiology,2005,151(Pt 9):2987-2999.
[6] Vylkova S, Jang WS, Li W, et al. Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 mitogen-activated protein kinase pathway[J]. Eukaryot Cell,2007,6(10):1876-1888.
[7] Robbins N, Uppuluri P, Nett J, et al. Hsp90 governs dispersion and drug resistance of fungal biofilms[J]. PLoS Pathog,2011,7(9):e1002257.
[8] de Dios CH, Roman E, Monge RA, et al. The role of MAPK signal transduction pathways in the response to oxidative stress in the fungal pathogen Candida albicans: implications in virulence[J]. Curr Protein Pept Sci,2010,11(8):693-703.
[9] Kelly J, Rowan R, Mccann M, et al. Exposure to caspofungin activates Cap and Hog pathways in Candida albicans[J]. Med Mycol,2009,47(7):697-706.
[10] Gonzalez-Parraga P, Alonso-Monge R, Pla J, et al. Adaptive tolerance to oxidative stress and the induction of antioxidant enzymatic activities in Candida albicans are independent of the Hog1 and Cap1-mediated pathways[J]. FEMS Yeast Res,2010,10(6):747-756.
[11] 陈裕充,温海,高平挥,等. MAPK转导通路在白念珠菌菌体抗氧化应激中的作用[J]. 中国真菌学杂志,2009,4(3):137-139.
[12] Whiteway M, Oberholzer U. Candida morphogenesis and host-pathogen interactions[J]. Curr Opin Microbiol,2004,7(4):350-357.
[13] Alonso-Monge R, Navarro-Garcia F, Molero G, et al. Role of the mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicans[J]. J Bacteriol,1999,181(10):3058-3068.
[14] Alonso-Monge R, Carvaihlo S, Nombela C, et al. The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans[J]. Microbiology,2009,155(Pt 2):413-423.
[15] Alonso-Monge R, Real E, Wojda I, et al. Hyperosmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects[J]. Mol Microbiol,2001,41(3):717-730.
[16] Lee CM, Nantel A, Jiang L, et al. The serine/threonine protein phosphatase SIT4 modulates yeast-to-hypha morphogenesis and virulence in Candida albicans[J]. Mol Microbiol,2004,51(3):691-709.
[17] Arana DM, Nombela C, Alonso-Monge R, et al. The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans[J]. Microbiology,2005,151(Pt 4):1033-1049.
[18] Navarro-Garcia F, Eisman B, Fiuza S M, et al. The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans[J]. Microbiology,2005,151(Pt 8):2737-2749.
[19] Shapiro RS, Uppuluri P, Zaas AK, et al. Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling[J]. Curr Biol,2009,19(8):621-629.
[20] Lafayette SL, Collins C, Zaas AK, et al. PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90[J]. PLoS Pathog,2010,6(8):e1001069.
[21] Leach MD, Budge S, Walker L, et al. Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast[J]. PLoS Pathog,2012,8(12):e1003069.
[22] Bates S, Maccallum D M, Bertram G, et al. Candida albicans Pmr1p, a secretory pathway P-type Ca²⁺/Mn²⁺-ATPase, is required for glycosylation and virulence[J]. J Biol Chem,2005,280(24):23408-23415.
[23] Whiteway M, Dignard D, Thomas DY. Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest[J]. Proc Natl Acad Sci USA,1992,89(20):9410-9414.
[24] Roman E, Nombela C, Pla J. The Sho1 adaptor protein links oxidative stress to morphogenesis and cell wall biosynthesis in the fungal pathogen Candida albicans[J]. Mol Cell Biol,2005,25(23):10611-10627.
[25] Eisman B, Alonso-Monge R, Roman E, et al. The Cek1 and Hog1 mitogen-activated protein kinases play complementary roles in cell wall biogenesis and chlamydospore formation in the fungal pathogen Candida albicans[J]. Eukaryot Cell,2006,5(2):347-358.
[26] Roman E, Cottier F, Ernst JF, et al. Msb2 signaling mucin controls activation of Cek1 mitogen-activated protein kinase in Candida albicans[J]. Eukaryot Cell,2009,8(8):1235-1249.
[27] Roman E, Alonso-Monge R, Gong Q, et al. The Cek1 MAPK is a short-lived protein regulated by quorum sensing in the fungal pathogen Candida albicans[J]. FEMS Yeast Res,2009,9(6):942-955.
[28] Mayer FL, Wilson D, Jacobsen ID, et al. Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans[J]. PLoS One,2012,7(6):e38584.
[29] Herrero DDC, Roman E, Diez C, et al. The transmembrane protein Opy2 mediates activation of the Cek1 MAP kinase in Candida albicans[J]. Fungal Genet Biol,2013,50:21-32.
[30] Szafranski-Schneider E, Swidergall M, Cottier F, et al. Msb2 shedding protects Candida albicans against antimicrobial peptides[J]. PLoS Pathog,2012,8(2):e1002501.
[31] Srinivasa K, Kim J, Yee S, et al. A MAP kinase pathway is implicated in the pseudohyphal induction by hydrogen peroxide in Candida albicans[J]. Mol Cells,2012,33(2):183-193.
[32] Chen J, Wang Q, Chen J Y. CEK2, a Novel MAPK from Candida albicans Complement the Mating Defect of fus3/kss1 Mutant[J]. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai),2000,32(3):299-304.
[33] 陈静,陈江野. CEK2和CSK1基因的敲除对白色念珠菌形态的影响[J]. 实验生物学报,2001,34(1):25-33.