A case of infant fixed sporotrichosis caused by Sporothrix globosa and laboratory study

Abstract

Abstract: A case of infant fixed sporotrichosis caused by Sporothrix globosa was reported.A 3-month-old infant was admitted with skin granulomatous lesions beside the left medial canthus for 2 months.Direct smear examination and fungal culture, carbon source assimilation, PCR and calmodulin sequence analysis were performed for diagnosis.The antifungals susceptibility was tested according to M27-A3 and M38-A2 published by CLSI. Flower-shaped conidia and sleeve-like hyphae were observed in the slide culture. Calmodulin sequence were amplified,and the product was sequenced,which was aligned with 100% sequential similarity to multiple sequences of Sporothrix globosa in the GenBank database.The MICs for terbinafine and itraconazole were 0.5 μg/mL and 0.5 μg/mL against hyphae phage of the strain and 0.25 μg/mL and 0.5 μg/mL against yeast phage. The lesion was cured after oral terbinafine for 10 weeks. The case of fixed sporotrichosis was caused by Sporothrix globosa, terbinafine has good effect.

Key words: infant, sporotrichosis, Sporothrix globosa, terbinafine

CLC Number:

R756.6

WANG Run-chao, WANG Ai-ping, WAN Zhe, LI Ruo-yu. A case of infant fixed sporotrichosis caused by Sporothrix globosa and laboratory study[J]. Chinese Journal of Mycology, 2013, 8(4): 228-231.

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