Advances in research on synergists of antifungal drug

Abstract

Abstract: Recently, antifungal resistance showed an increasing trend, especially, the resistance to azole antifungal agents such as fluconazole is the most serious, which attributes to one of the reasons for treatment failure. Increasing dosage of drug or drug combination therapy are common methods to treat drug-resistant fungal. Moreover, it is reported that some plant extracts or small molecules can significantly increase the susceptibility of antifungal drug against resistant isolates. The synergistic effect of two agents is expected to be a new strategy to combat resistant fungal. Herein, we reviewed the advances in research on the sensitizer of antifungal drugs at home and abroad.

Key words: antifungal resistance, synergist, anti-fungal

CLC Number:

R978.5

DAI Li, JIANG Yuan-ying, ZHANG Da-zhi. Advances in research on synergists of antifungal drug[J]. Chinese Journal of Mycology, 2013, 8(2): 116-119.

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