Abstract: Objective To discuss the clinical features of multiple myeloma who complicated with upper gastrointestinal invasive candidiasis, and improve our knowledge about this disease. Methods We retrospectively analysed two patients with multiple myeloma complicated with upper gastrointestinal invasive candidiasis, and reviewed literature about this disease to understanding it's risk factors, clinical fature, diagnosis, differential diagnosis and therapy. Result Case 1 A woman was diagnosed a κ light chain multiple myeloma for which she successfully underwent allo-bone marrow transplant. 4 months later she developed diarrhea and pain of belly, anti GVHD treatment was inefficiency. By electronic gastroscopy she was diagnosed upper gastrointestinal invasive candidiasis, and was cured by infusing caspofungin. Case 2 A man was diagnosed an IgG λ multiple myeloma for which he unsuccessfully underwent chemotherapy. With progression of the disease, he developmented abdominal distension,belly pain, heart failure, renal failure as well as pulmonary candidiasis. By electronic gastroscopy he was diagnose upper gastrointestinal invasive candidiasis.Treating with itraconazole and caspofungin were futility, and soonly died of multi-organic failure and cadidiasis infection. Conclusion We explored the clinical features of the disease and found it's prone to misdiagnosis. Clinician need enhance the knowledge of the disease, and electronic gastroscopy is essential for diagnosis as well as assessment of treatment effect.

Key words: multiple myeloma, gastrointestinal candidiasis, invasive fungal infection