Primary cutaneous zygomycosis caused by Rhizomucor variabilis in China：a review of 13 cases

Abstract

Abstract: Objective To investigate the epidemic and clinical characteristics of primary cutaneous zygomycosis due to Rhizomucor variabilis in China since 1991.Methods Thirteen cases of cutaneous mucormycosis caused by Rhizomucor variabilis were searched from the electrical database, and all the clinical information was collected and evaluated.Results Of the 13 case records, 7 were female while 6 were male.Median age was 34?17 (5-65) year and the course ranged from 5 months to 16 years. Most cases were mainly reported in Yangtze River valley. The major clinical manifestations were local erythema, papula, and/or nodule, which might spread into infiltrating plaque associated with ulceration and necrosis. Six patients had defined mucocutaneous damage histories before the onset. All the lesions primarily occurred in exposure parts of the body (10 in the face and 3 in the upper limb) and all the diagnoses were made by mycological and histopathological examinations.The major treatments were amphotericin B and azole drugs.Eight patients were cured, and two had poor results while three lost follow-up.Conclusions Primary cutaneous zygomycosis due to Rhizomucor variabilis is severe disfiguring disease. Enhancing the understanding of its clinical characterisctics will contribute to the early diagnosis and timely treatment, and amphotericin B should be considered as a preferred choice.

Key words: Zygomycosis, Rhizomucor variabilis, cutaneous infection

CLC Number:

R756.6

SHANG Yi, FANG Wei, LIAO Wan-qing. Primary cutaneous zygomycosis caused by Rhizomucor variabilis in China：a review of 13 cases[J]. Chinese Journal of Mycology, 2013, 8(1): 30-34.

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