Abstract: Objective To investigate the risk factors, the pathogen classification,clinical characteristics and prevention countermeasures of hospital fungal infection in Bullous disease patients treated with corticosteroids.Methods Sixty-seven patients with bullous pemphigoid and 38 patients with pemphigus treated with glucocorticoid were enrolled in this study. Their clinical data were collected to calculate the rate of hospital fungal infection and analysize its related risk factors.Results The rate of hospital fungal infection was 32.38% in Bullous disease patients treated with corticosteroids. The rates of oral and pulmonary fungal infections were 27.61% and 13.33%, and the main pathogens included C. albicans (69.77%), C. tropical (11.63%) and C. parapsilosis (6.98%). The fungal infections were obviously associated with corticosteroids doses, inmunoinhibitors, antibiotics and the history of diabetes, and immune inhibitors, antibiotics. History of diabetes were considered as the independent risk factors.Conclusion A high incidence of fungal infection was found in Bullous disease patients treated with corticosteroids. The inmunoinhibitors, antibiotics and history of diabetes were the main risk factors.

Key words: Bullous disease, corticosteroids, fungal infection, prevention