Invasive pulmonary aspergillosis in autoimmune bullous diseases patients:three cases report

Abstract

Abstract: Objective To study the diagnosis and treatment of invasive pulmonary aspergillosis in autoimmune bullous diseases patients under long-term glucocorticoids treatment by retrospectively reviewing three cases.Methods Report three cases of autoimmune bullous diseases with invasive pulmonary aspergillosis. KOH smear and culture, antigen detection, chest CT scan and histopathologic test were used to diagnose the patients. The organisms isolated from the sputum were identified as Aspergillus fumigatus, A. flavus and Emericella echinulata by morphological and molecular methods.Results Three cases were diagnosed as invasive pulmonary aspergillosis. The patients were cured with voriconazole treatment and other antifungal agents.Conclusion Autoimmune bullous diseases patients should be watched out emerging invasive apergillosis during long-term glucocorticoids therapy. Combined laboratory examinations will be helpful in early diagnosis and increasing efficacy.

Key words: autoimmune bullous diseases, glucocorticoids, invasive pulmonary aspergillosis

CLC Number:

R563.19

YU Jin, MU Xiang-dong, WAN Zhe, QUE Cheng-li, LI Ruo-yu. Invasive pulmonary aspergillosis in autoimmune bullous diseases patients:three cases report[J]. Chinese Journal of Mycology, 2012, (4): 214-218.

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