Effect of mannose receptor of alveolar macrophage on cryptococcal pneumonia in immunodepressive rats

Abstract

Abstract: Objective To explore the effect of mannose receptor of alveolar macrophage on cryptococcal pneumonia in immunodepressive rats.Methods Immunodepressive rats model was set up to observe the influence of immunodepression on the expression of mannose receptors by flow cytometry.The alveolar macrophages were cocultured with Cryptococcus neoformans and the phagocytosis was observered.Results On the endpoint of the observation, the expression of mannose receptors and the phagotosis of Cryptococcus neoformans in immunodepressive rats showed no significant difference with those in normal rats.Conclusions Immunodeficiency is not the key factor for the expression of mannose receptors.

Key words: alveolar macrophage, mannose receptor, Cryptococcus neoformans, immunosuppression

CLC Number:

R 379.5

XU Nan, XIAO Qin, YAO Wei, CHU Wei-fang, XIAO Xiao-qing, GU Ju-lin, WEN Hai. Effect of mannose receptor of alveolar macrophage on cryptococcal pneumonia in immunodepressive rats[J]. Chinese Journal of Mycology, 2012, 7(3): 146-149,167.

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