Analysis of invasive fungal infections in patients with chronic severe hepatitis B

Abstract

Abstract: Objective To investigate the incidence and cause of invasive fungal infections in patients with chronic severe hepatitis B.Methods A total of 126 chronic severe hepatitis B patients hospitalized in Changzheng Hospital from Jan 2006 to Jan 2009 were recruited,including 60 cases with proven or probable IFIs and 66 cases without IFIs.Epidemiology,risk factors and mortality of IFIs were retrospectively analyzed in this present study.Results The incidence of IFIs was 5% (60/1200) and 47.62% (60/126) in chronic hepatitis B patients and chronic severe hepatitis B patients,respectively.Logistic analysis showed that HBV DNA copy was the most important risk factor of IFIs (P=0.000,OR=1.813,95% CI=1.461～2.252).ROC line analysis revealed that the diagnostic critical value of DNA copy for IFIs was 3.16×10³copies/mL,indicating IFIs would possibly occur if DNA copy was higher than 3.16×10³copies/mL.Conclusions The morbidity of IFIs in patients with chronic severe hepatitis B is unpredictably high.To lower the DNA copies could alleviate the progression of chronic hepatitis B,which is important for prevention and trentment of IFIs.

Key words: Chronic severe hepatitis B, invasive fungal infections, DNA, risk factor, Candida albicans

CLC Number:

R756.6

ZHU Ding-heng, CHE Fu-bin, WEN Hai, GU Ju-lin, CHEN Jiang-han. Analysis of invasive fungal infections in patients with chronic severe hepatitis B[J]. Chinese Journal of Mycology, 2010, 5(2): 78-81.

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