Abstract: Objective To analyze the clinical and laboratory features of penicilliosis marneffei (PSM).Methods Clinical and laboratory features of eight patients with PSM from our department during 2003-2009 were retrospectively analyzed.Results ① Penicillium marneffei infections commonly occurred in HIV-infected patients or AIDS patients.②The skin lesions including red-dish papulovesicles,necrotizing papules,molluscum contagiosum-like papules,ulcers and blood scab and systemic symptoms might appear simultaneously or successively.③Multiple organs could be involved.④ Penicillium marneffei showed yeast-phase at 37℃, but mycelial phase at 25℃.Typical " mulberry-like" changes were observed histopathologically.Conclusions PSM often occurs in the HIV-infected patients or other immunosuppressive patients.It characteristics of mycology and histopathology is key for diagnosis.

Key words: Penicillium marneffei, penicilliosis marneffei, skin, HIV infection