Abstract: Objective To investigate the clinical manifestation,treatment and prognosis of AIDS with penicilliosis marneffei.Methods Thirty-six cases of AIDS with penicilliosis marneffei treated in our hospital between August 2008 to August 2009 were retrospectively analyzed.Results The average age of 36 patients of AIDS with penicilliosis marneffei was 35.8.Clinical manifestations of Penicillium marneffei infection were non-specific,including fever (86.11%),anemia (94.44%),GGT increasing (69.44%), AST increasing (63.89%),generalized lymphadenopathy (88.89%),splenomegaly (63.89%),hypoproteinemia (83.33%), cough (36.11%),cutaneous manifestations (30.56%) (typical changes,13.89%),CD₄⁺< 50 cells/mm³(88.89%).Bone marrow aspirates culture (27 /27) and skin lesions biopsy specimen culture was 100% positive,while blood culture rate was 69.44% (25/36).Thirty-six patients received antifungal therapy,of which 29 patients were treated by HAART therapy with 28 cases cured, 7 cases improved,1 dead with MOF.Conclusions Penicillium marneffei is a common opportunistic pathogen of AIDS.Early detection,early treatment and long-range-sensitive antifungal combination therapy may helpful for cure rate improvement and recurrence reduction.

Key words: AIDS, Penicillium marneffei, opportunistic infection, clinical analysis, therapy